Hyperbaric oxygen therapy might improve certain pathophysiological findings in autism.

@article{Rossignol2007HyperbaricOT,
  title={Hyperbaric oxygen therapy might improve certain pathophysiological findings in autism.},
  author={Daniel A Rossignol},
  journal={Medical hypotheses},
  year={2007},
  volume={68 6},
  pages={
          1208-27
        }
}
  • D. Rossignol
  • Published 2007
  • Biology, Medicine
  • Medical hypotheses

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References

SHOWING 1-10 OF 284 REFERENCES
Hyperbaric oxygen therapy may improve symptoms in autistic children.
Immunity, neuroglia and neuroinflammation in autism
TLDR
The presence of neuroglial and innate neuroimmune system activation in brain tissue and cerebrospinal fluid of patients with autism is demonstrated, findings that support the view that neuroimmune abnormalities occur in the brain of autistic patients and may contribute to the diversity of the autistic phenotypes.
Neuroglial activation and neuroinflammation in the brain of patients with autism
TLDR
It is indicated that innate neuroimmune reactions play a pathogenic role in an undefined proportion of autistic patients, suggesting that future therapies might involve modifying neuroglial responses in the brain.
Altered vascular phenotype in autism: correlation with oxidative stress.
TLDR
Besides enhanced oxidative stress, platelet and vascular endothelium activation also could contribute to the development and clinical manifestations of autism.
Mitochondrial dysfunction in autism spectrum disorders: a population-based study.
TLDR
Five of 11 patients studied were classified with definite mitochondrial respiratory chain disorder, suggesting that this might be one of the most common disorders associated with autism and warranting further investigation.
Metabolic endophenotype and related genotypes are associated with oxidative stress in children with autism
  • S. J. JamesS. Melnyk D. Gaylor
  • Biology
    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2006
TLDR
It is proposed that an increased vulnerability to oxidative stress (endogenous or environmental) may contribute to the development and clinical manifestations of autism.
Heat shock protein 90 antibodies in autism
TLDR
Whether a subset of autistic individuals had elevated levels of autoantibodies to hsp90 compared to other study populations was aimed at, based on serendipitous observation of a 90 kDa molecular weight protein in Western blots of the serum of autistic Individuals with compulsive symptomatology that were being analyzed for a different study.
Changes in nitric oxide levels and antioxidant enzyme activities may have a role in the pathophysiological mechanisms involved in autism.
IMPROVEMENT IN CEREBRAL METABOLISM IN CHRONIC BRAIN INJURY AFTER HYPERBARIC OXYGEN THERAPY
TLDR
The results provided the first statistical research data to show the effectiveness of HBOT in improving blood flow in CND and indicate that HBOT can be an effective part of the treatment for such clients.
Investigation of antioxidant enzymes in children with autistic disorder.
TLDR
The results indicate that autistic children have low levels of activity of blood antioxidant enzyme systems; if similar abnormalities are present in brain, free radical accumulation could damage brain tissue.
...
...