Hyperbaric oxygen therapy for the treatment of traumatic brain injury: a meta-analysis

@article{Wang2015HyperbaricOT,
  title={Hyperbaric oxygen therapy for the treatment of traumatic brain injury: a meta-analysis},
  author={Fei Wang and Yong Wang and Tao Sun and Hua-lin Yu},
  journal={Neurological Sciences},
  year={2015},
  volume={37},
  pages={693-701}
}
Compelling evidence suggests the advantage of hyperbaric oxygen therapy (HBOT) in traumatic brain injury. [] Key Method Prospective studies comparing hyperbaric oxygen therapy vs. control in patients with mild (GCS 13–15) to severe (GCS 3–8) TBI were hand-searched from medical databases using the terms “hyperbaric oxygen therapy, traumatic brain injury, and post-concussion syndrome”.
Hyperbaric oxygen for severe traumatic brain injury: a randomized trial
TLDR
Hyperbaric oxygen therapy may promote recovery of neurological function and improve the cognitive function and prognosis of patients with severe traumatic brain injury.
Hyperbaric Oxygenation in the Treatment of Traumatic Brain Injury
TLDR
Evidence-based and clinical medicine data show the safety, efficacy and cost effectiveness of HBOT as a standard of care that should be put on-label and insured.
Effects of Magnesium Sulfate Therapy on GCS Scores in Patients with Severe Traumatic Brain Injury
TLDR
A significant improvement was found in the GCS after magnesium sulfate therapy in patients with TBI, and this difference was not statistically significant.
Evidence brief: hyperbaric oxygen therapy (HBOT) for traumatic brain injury and/or post-traumatic stress disorder.
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TLDR
The authors suggest that in Veterans who have not responded to other therapeutic options, the use of HBOT is "reasonable" and allow for a similar recommendation for any unproven therapeutic option where there is no clearly effective treatment available and is, to this reviewer, unacceptable.
Efficacy and Prognosis of Hyperbaric Oxygen as Adjuvant Therapy for Neonatal Hypoxic-Ischemic Encephalopathy: A Meta-Analysis Study
TLDR
A meta-analysis suggested that HBOT can be a potential therapy for the treatment of neonatal HIE, and the heterogeneity of studies protocol and patient selection being only from China means more research is needed before this therapy can be widely implemented in the clinic.
Traumatic brain injured patients: primum non nocere
TLDR
Prehospital and neuro ICU management of TBI patients can significantly improve patient outcome, however, it is important to also consider whether these patients would actually want to be treated particularly in the elderly population.
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TLDR
It is suggested that hyperbaric oxygen therapy (HBOT) can be recommended as an effective and safe complementary therapy for the treatment of VD.
Hippocampal cerebral blood flow increased following low-pressure hyperbaric oxygenation in firefighters with mild traumatic brain injury and emotional distress
TLDR
It is demonstrated that low-pressure HBO might increase rCBF of the hippocampal and parahippocampal regions, suggesting a potential underpinning mechanism of HBO in the human brain.
An Extra Breath of Fresh Air: Hyperbaric Oxygenation as a Stroke Therapeutic
TLDR
Evidence on the use of hyperbaric oxygen therapy following an ischemic stroke is examined, and the potential for HBOT preconditioning as a neuroprotective strategy is explored, thus maximizing theUse of HBOT for isChemic stroke.
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References

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Effect of hyperbaric oxygen on patients with traumatic brain injury.
TLDR
HBOT can provide some benefits for the subacute TBI patients with minimal adverse side effects, and significant GOS improvement was observed in the HBOT group 6 months after HBOT.
Hyperbaric oxygen therapy for the adjunctive treatment of traumatic brain injury.
TLDR
In people with traumatic brain injury, the addition ofHBOT significantly reduced the risk of death but not of favourable clinical outcome, and the routine application of HBOT to these patients cannot be justified from this review.
Hyperbaric Oxygen Therapy Can Improve Post Concussion Syndrome Years after Mild Traumatic Brain Injury - Randomized Prospective Trial
TLDR
HBOT can induce neuroplasticity leading to repair of chronically impaired brain functions and improved quality of life in mTBI patients with prolonged PCS at late chronic stage.
Hyperbaric oxygen therapy for traumatic brain injury
TLDR
Hyperbaric oxygen therapy may serve as a promising neuroprotective strategy that when combined with other therapeutic targets for TBI patients which could improve long-term outcomes.
The effect of hyperbaric oxygen on symptoms after mild traumatic brain injury.
TLDR
This study showed that HBO₂ at 2.4 ATA pressure had no effect on post-concussive symptoms after mild TBI.
A phase I study of low-pressure hyperbaric oxygen therapy for blast-induced post-concussion syndrome and post-traumatic stress disorder.
TLDR
Forty 1.5 ATA HBOT sessions in 1 month was safe in a military cohort with chronic blast-induced PCS and PTSD, with concomitant significant improvements in SPECT.
Observation of curative effects of hyperbaric oxygen for treatment on severe craniocerebral injury
TLDR
The curative effects of hyperbaric oxygen for treatment on severe craniocerebral injury gets better when basic treatment combined with HBO treatment.
The Effect of Hyperbaric Oxygen on Persistent Postconcussion Symptoms
TLDR
It is demonstrated that HBO2 at either 1.5 or 2.0 ATA equivalent had no effect on postconcussion symptoms after mild traumatic brain injury when compared with sham compression.
Results of a prospective randomized trial for treatment of severely brain-injured patients with hyperbaric oxygen.
TLDR
Analysis of the outcome of survivors reveals that hyperbaric oxygen treatment did not increase the number of patients in the favorable outcome categories (good recovery and moderate disability), and the possibility that a different hyperbarics oxygen treatment paradigm or the addition of other agents, such as a 21-aminosteroid, may improve quality of survival is being explored.
A prospective, randomized clinical trial to compare the effect of hyperbaric to normobaric hyperoxia on cerebral metabolism, intracranial pressure, and oxygen toxicity in severe traumatic brain injury.
TLDR
Hyperbaric O2 has a more robust posttreatment effect than NBH on oxidative cerebral metabolism related to its ability to produce a brain tissue PO2 > or = 200 mm Hg, and it appears that O2 treatment for severe TBI is not an all or nothing phenomenon but represents a graduated effect.
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