Hyperbaric oxygen therapy for severe ulcerative colitis.

  title={Hyperbaric oxygen therapy for severe ulcerative colitis.},
  author={Alan L. Buchman and Caroline Fife and Carlos Torres and Lucy Smith and Juan Carlos Aristizibal},
  journal={Journal of clinical gastroenterology},
  volume={33 4},
Hyperbaric oxygen therapy has been used to successfully treat perineal Crohn's disease. We describe the first successful use of hyperbaric oxygen therapy in the treatment of ulcerative colitis, refractory to conventional therapies. Therapy consisted of 30 courses of 100% oxygen at a pressure of 2.0 atm absolute. Clinical remission was achieved on the basis of the Truelove-Witts and disease activity index scores. Corticosteroids were successfully tapered off once remission was achieved. 

Systematic review: the safety and efficacy of hyperbaric oxygen therapy for inflammatory bowel disease

Hyperbaric oxygen therapy (HBOT) provides 100% oxygen under pressure, which increases tissue oxygen levels, relieves hypoxia and alters inflammatory pathways. Although there is experience using HBOT

Hyperbaric oxygen therapy does not improve the effects of standardized treatment in a severe attack of ulcerative colitis: a prospective randomized study

The study results do not support the use of HBOT as a treatment option in a severe attack of UC and the authors found no statistically significant differences between the treatment groups in any of the assessed variables.

Hyperbaric oxygen therapy stimulates colonic stem cells and induces mucosal healing in patients with refractory ulcerative colitis: a prospective case series

Hyperbaric oxygen therapy (HBOT) stimulates colonic stem cells to promote healing and is effective in the setting of refractory ulcerative colitis.

The role of hyperbaric oxygen therapy in inflammatory bowel disease: a narrative review

Clinical and experimental studies have revealed that HBOT may exert its therapeutic effect by inhibiting inflammation and strengthening the antioxidant system, promoting the differentiation of colonic stem cells and recruiting cells involved in repair.

A Review of Hyperbaric Oxygen Therapy for Inflammatory Bowel Disease

The findings from the review have suggested that hyperbaric therapy can be an effective adjunctive approach for IBD, based on which some ideas for future clinical and research work are provided.

Hyperbaric Oxygen Therapy (HBOT) as a Therapeutic Option for Patients with Atopic Dermatitis (AD) – Own Experiences and Literature Review

An overall improvement in the clinical status and a decrease in the level of immunoglobulin E and C3 complement following a cycle of exposures may be indicative of an immunomodulating HBOT effect on AD, whereas hyperbaric oxygenation may constitute a therapeutic option for some patients with AD, especially those exhibiting a poor response to standard treatment.


In this minireview, bed baseline premises for the exploitation of oxygen facilities at higher pressure for healing of auditory system are described.

HBO Therapy in Gastroenterology

This chapter deals with a wide variety of HBO applications involving the gastrointestinal tract, including its use in dealing with peptic ulceration, intestinal obstruction, adynamic ileus, adhesive

Hyperbaric Oxygen Therapy in Systemic Inflammatory Response Syndrome

It is concluded that HBOT may be safe and tolerable for SIRS-positive dogs, and that it should be applied as early as possible.

Hyperbaric oxygen therapy ameliorates TNBS-induced acute distal colitis in rats

The results indicate that hyperbaric oxygen attenuates the severity of acute distal colitis through the down-regulation of pro-inflammatory events.



Hyperbaric oxygen for perianal Crohn's disease.

A trial of hyperbaric oxygen therapy in 10 patients with refractory perianal Crohn's disease confirmed that HBO therapy is a safe and efficient therapeutic option for perianals disease.

Hyperbaric oxygen: a novel modality to ameliorate experimental colitis

HBO effectively decreases colitis induced by acetic acid and TNB and suggests that reduction in NO generation may be among the mechanisms responsible for the anti-inflammatory effect of HBO.

Hyperbaric-oxygen therapy.

The mechanisms of action, evidence of clinical efficacy, and risks of therapy with hyperbaric oxygen are reviewed, and the risks and benefits of therapy are reviewed.

Effect of hyperbaric oxygenation on macrophage function in mice.

Exposure to hyperbaric oxygen induces tumour necrosis factor‐alpha (TNF‐α) secretion from rat macrophages

Evidence is provided in support of a role played by TNF‐α in mediating HBO effects on different tissues and their immune responses after a single exposure to a therapeutic profile of hyperbaric oxygen.

Mucosal capillary thrombi in rectal biopsies

Thrombi were observed in 8/13 cases of ulcerative colitis, 4/10 cases of Crohn's disease, 1/3 cases of unspecified inflammatory bowel disease and 5/20 cases of self‐limited colitis; the presence of capillary thrombi was not related to the severity of inflammation, but none of the control biopsies showed capillary Thrombi.