Hyperbaric oxygen therapy for severe ulcerative colitis.

@article{Buchman2001HyperbaricOT,
  title={Hyperbaric oxygen therapy for severe ulcerative colitis.},
  author={Alan L. Buchman and Caroline Fife and Carlos Torres and Lucy Smith and Juan Carlos Aristizibal},
  journal={Journal of clinical gastroenterology},
  year={2001},
  volume={33 4},
  pages={
          337-9
        }
}
Hyperbaric oxygen therapy has been used to successfully treat perineal Crohn's disease. We describe the first successful use of hyperbaric oxygen therapy in the treatment of ulcerative colitis, refractory to conventional therapies. Therapy consisted of 30 courses of 100% oxygen at a pressure of 2.0 atm absolute. Clinical remission was achieved on the basis of the Truelove-Witts and disease activity index scores. Corticosteroids were successfully tapered off once remission was achieved. 

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References

SHOWING 1-10 OF 29 REFERENCES

Hyperbaric oxygen for perianal Crohn's disease.

A trial of hyperbaric oxygen therapy in 10 patients with refractory perianal Crohn's disease confirmed that HBO therapy is a safe and efficient therapeutic option for perianals disease.

Hyperbaric oxygenation in severe perineal Crohn's disease

HBO might be useful as a last resort treatment of chronic perineal Crohn's disease, resistant to other treatments or as a complement to surgery.

Hyperbaric oxygen: a novel modality to ameliorate experimental colitis

HBO effectively decreases colitis induced by acetic acid and TNB and suggests that reduction in NO generation may be among the mechanisms responsible for the anti-inflammatory effect of HBO.

Hyperbaric-oxygen therapy.

The mechanisms of action, evidence of clinical efficacy, and risks of therapy with hyperbaric oxygen are reviewed, and the risks and benefits of therapy are reviewed.

Effect of hyperbaric oxygenation on macrophage function in mice.

Biopsy Studies in Ulcerative Colitis

The main object in the present paper is to present the relationships between the clinical state, sigmoidoscopic appearance, and histological findings in serial biopsy studies of the colonic mucosa in ulcerative colitis.

Thromboembolism in inflammatory bowel disease: role of platelets.

Patients with inflammatory bowel disease have abnormal platelet activity, which may contribute to the inflammatory process and platelet lifespan studies were normal, and there was no correlation with disease activity.

Exposure to hyperbaric oxygen induces tumour necrosis factor‐alpha (TNF‐α) secretion from rat macrophages

Evidence is provided in support of a role played by TNF‐α in mediating HBO effects on different tissues and their immune responses after a single exposure to a therapeutic profile of hyperbaric oxygen.