Hyperbaric oxygen may induce angiogenesis in patients suffering from prolonged post-concussion syndrome due to traumatic brain injury.

@article{Tal2015HyperbaricOM,
  title={Hyperbaric oxygen may induce angiogenesis in patients suffering from prolonged post-concussion syndrome due to traumatic brain injury.},
  author={Sigal Tal and Amir Hadanny and Nadav Berkovitz and Efrat Sasson and Eshel Ben-Jacob and Shai Efrati},
  journal={Restorative neurology and neuroscience},
  year={2015},
  volume={33 6},
  pages={
          943-51
        }
}
PURPOSE Recent clinical studies present convincing evidence that hyperbaric oxygen therapy (HBOT) may be the coveted neurotherapeutic method for brain repair. One of the most interesting ways in which HBOT can induce neuroplasticity is angiogenesis. The objective in this study was to assess the neurotherapeutic effect of HBOT in post TBI patients using brain perfusion imaging and clinical cognitive functions. METHODS Retrospective analysis of patients suffering from chronic neuro-cognitive… 
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Hyperbaric Oxygen Therapy Can Induce Angiogenesis and Regeneration of Nerve Fibers in Traumatic Brain Injury Patients
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Clinically, HBOT induced significant improvement in the memory, executive functions, information processing speed and global cognitive scores and the mechanisms by which HBOT induces brain neuroplasticity can be demonstrated by highly sensitive MRI techniques of DSC and DTI.
Effect of hyperbaric oxygen therapy on chronic neurocognitive deficits of post-traumatic brain injury patients: retrospective analysis
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In the largest published cohort of patients suffering from chronic deficits post-TBI of all severities, HBOT was associated with significant cognitive improvements and the clinical improvements were well correlated with increased activity in the relevant brain areas.
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Irrespective to treatment protocol HBOT appeared to alleviate the detrimental and neurotoxic effects of pathological sequel initiated by TBI and to stimulate endogenous reparative mechanisms, however, the exact mechanisms by which HBOT exerts its beneficial effects on recovery after brain injury are still deficient.
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HBOT induces significant improvements in all cognitive domains even in the late chronic stage, and the selection of post-stroke patients for HBOT should be based on functional analysis and baseline cognitive scores rather than the stroke type, location or side of lesion.
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A summary of the current understanding of hyperbaric oxygen therapy (HBOT) as well as suggests future directions including prophylactic use and chronic treatment.
The efficacy and safety of hyperbaric oxygen therapy in traumatic brain injury
TLDR
There is significant evidence from multiple pre-clinical studies on the beneficial effects of HBOT for the treatment of traumatic brain injury (TBI); however, more clinical data is needed.
Management of Acute Ischemic Hypoxic Encephalopathy in Newborns with Hyperbaric Oxygen: A Review
  • Medicine
  • 2016
TLDR
HBO2 promotes survival of marginal tissue (penumbra), reduces edema, improves microcirculation, breaks the edema-hypoxia-edema vicious cycle, enhances healing, promotes growth factors up-regulation and improves neovascularization, and can modify cerebral inflammation, ischemia, hypoxia, andIschemia-reperfusion injury.
Hyperbaric Oxygen Therapy Can Induce Neuroplasticity and Significant Clinical Improvement in Patients Suffering From Fibromyalgia With a History of Childhood Sexual Abuse—Randomized Controlled Trial
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HBOT induced significant clinical improvement that correlates with improved brain functionality and brain microstructure in CSA related FMS patients, and there was a significant improvement in all FMS questionnaires and most domains of quality of life, PTSD symptoms and psychological distress.
Hyperbaric Oxygen Treatment—From Mechanisms to Cognitive Improvement
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Hyperbaric oxygen treatment is becoming a major player in 21st century research and clinical treatments, including the treatment of neurological and neurodegenerative diseases and improvement of cognition and brain metabolism in cases of mild cognitive impairment.
Treatment of persistent post-concussion syndrome due to mild traumatic brain injury: current status and future directions
TLDR
A most promising new direction is the use of hyperbaric oxygen therapy, which targets the basic pathological processes responsible for post-concussion symptoms; it is discussed here in depth.
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