Hyperbaric oxygen induces VEGF expression through ERK, JNK and c-Jun/AP-1 activation in human umbilical vein endothelial cells.

@article{Lee2006HyperbaricOI,
  title={Hyperbaric oxygen induces VEGF expression through ERK, JNK and c-Jun/AP-1 activation in human umbilical vein endothelial cells.},
  author={Chun-chung Lee and Shu-Chen Chen and S R Tsai and B Wang and Ya-Chen Liu and Horng-mo Lee and Kou-Gi Shyu},
  journal={Journal of biomedical science},
  year={2006},
  volume={13 1},
  pages={143-56}
}
Hyperbaric oxygen (HBO) is increasingly used in a number of areas of medical practice, such as selected problem infections and wounds. The beneficial effects of HBO in treating ischemia-related wounds may be mediated by stimulating angiogenesis. We sought to investigate VEGF, the main angiogenic regulator, regulated by HBO in human umbilical vein endothelial cells (HUVECs). In this study, we found that VEGF was up regulated both at mRNA and protein levels in HUVECs treated with HBO dose- and… CONTINUE READING
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