Hyperbaric oxygen in traumatic brain injury

@article{Rockswold2007HyperbaricOI,
  title={Hyperbaric oxygen in traumatic brain injury},
  author={Sarah B. Rockswold and Gaylan L. Rockswold and Archie Defillo},
  journal={Neurological Research},
  year={2007},
  volume={29},
  pages={162 - 172}
}
Abstract Objectives: This critical literature review examines historical and current investigations on the efficacy and mechanisms of hyperbaric oxygen (HBO) treatment in traumatic brain injury (TBI). Potential safety risks and oxygen toxicity, as well as HBO's future potential, are also discussed. Methods: Directed literature review. Results: Historically, cerebral vasoconstriction and increased oxygen availability were seen as the primary mechanisms of HBO in TBI. HBO now appears to be… 
Hyperbaric oxygenation as an adjuvant therapy for traumatic brain injury: a review of literature
TLDR
The results from the experimental studies indicate that HBO can preserve mitochondrial function, reduce apoptosis and neuroinflammation and promote neuronal plasticity, and conducting of methodologically-based multicentric clinical trials is necessary to determine proper guidelines for inclusion of TBI patients in HBOT.
Hyperbaric Oxygen Therapy in Traumatic Brain Injury: Cellular and Molecular Mechanisms
TLDR
Irrespective to treatment protocol HBOT appeared to alleviate the detrimental and neurotoxic effects of pathological sequel initiated by TBI and to stimulate endogenous reparative mechanisms, however, the exact mechanisms by which HBOT exerts its beneficial effects on recovery after brain injury are still deficient.
Title : Neuroprotective effects of hyperbaric oxygen treatment on traumatic brain injury in the rat
TLDR
HBO treatment could alleviate brain damage after TBI; a single treatment with HBO has a time limitation of 12 h post-TBI; multiple HBO treatments have the possibility to extend the post- TBI delivery time window; and the results suggest the validity of HBO therapy for the treatment of TBI.
Hyperbaric oxygen therapy for the adjunctive treatment of traumatic brain injury.
TLDR
The results of two studies indicate use of HBOT results in a statistically significant decrease in the proportion of people with an unfavourable outcome one month after treatment using the Glasgow Outcome Scale, so the benefits and risks of the therapy need to be carefully evaluated.
Neuroprotective effects of hyperbaric oxygen treatment on traumatic brain injury in the rat.
TLDR
HBO treatment could alleviate brain damage after TBI; a single treatment with HBO has a time limitation of 12 h post-TBI; and multiple HBO treatments have the possibility to extend the post- TBI delivery time window.
Effect of hyperbaric oxygen on patients with traumatic brain injury.
TLDR
HBOT can provide some benefits for the subacute TBI patients with minimal adverse side effects, and significant GOS improvement was observed in the HBOT group 6 months after HBOT.
Hyperbaric Oxygen Therapy Ameliorates Local Brain Metabolism, Brain Edema and Inflammatory Response in a Blast-Induced Traumatic Brain Injury Model in Rabbits
TLDR
The results demonstrate that hyperbaric oxygen could confer neuroprotection and improve prognosis after explosive injury by promoting the metabolism of local neurons, inhibiting brain edema, protecting BBB integrity, decreasing cell apoptosis, and inhibiting the inflammatory response.
Hyperbaric Oxygen therapy of Severe traumatic Brain Injury in Children and Adolescents
TLDR
HBOt appears to be beneficial as an adjunctive treatment in children and adolescents with disturbed consciousness following an acute treatment of severe tBI with no major adverse events.
Quantitative evaluation of hyperbaric oxygen efficacy in experimental traumatic brain injury: an MRI study
TLDR
HBO could improve the impaired BBB and cytotoxic edema after TBI and promote the recovery of neurofunction.
Traumatic brain injury : Current endeavours and trends for neuroprotection and related recovery
TLDR
Novel achievements in neuroprotection are now expected from developing antiapoptotic agents, from more potent antioxidants, cholinergic agents, alpha blockers from researching various physiologic substances, including from regenerative medicine and physiatric, assisstive technology/ bioengineering advancements.
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References

SHOWING 1-10 OF 105 REFERENCES
Effects of hyperbaric oxygenation therapy on cerebral metabolism and intracranial pressure in severely brain injured patients.
TLDR
The increased CMRO2 and decreased CSF lactate levels after treatment indicate that HBO may improve aerobic metabolism in severely brain injured patients and assert that shorter, more frequent exposure to HBO may optimize treatment.
Hyperbaric oxygenation for severe head injuries. Preliminary results of a controlled study.
TLDR
Analysis of results in subgroups revealed that, in one subgroup, the rate of recovered consciousness at 1 month was significantly higher when OHP was used, and the view is defended that, besides its toxic action on the normal nervous tissue, OHP can counteract edema and ischemia in the zones of brain injuries.
Effects of hyperbaric oxygen therapy on cerebral oxygenation and mitochondrial function following moderate lateral fluid-percussion injury in rats.
TLDR
Analysis of data demonstrates that HBO significantly increases brain tissue PO2 after injury and that the recovery of aerobic metabolic function may be enhanced by treatment with HBO and that mitochondrial function is depressed by injury.
Impaired cerebral mitochondrial function after traumatic brain injury in humans.
OBJECT Oxygen supply to the brain is often insufficient after traumatic brain injury (TBI), and this results in decreased energy production (adenosine triphosphate [ATP]) with consequent neuronal
Brain oxygen tension in severe head injury.
TLDR
Monitoring the partial oxygen pressure of local brain tissue is a safe and reliable method for regulating cerebral oxygenation and whether therapeutic approaches can be targeted on the basis of such monitoring is questioned.
Hyperbaric oxygen after global cerebral ischemia in rabbits reduces brain vascular permeability and blood flow.
TLDR
HBO administered after global cerebral ischemia promoted blood-brain barrier integrity and reduced cerebral blood flow; this effect was not associated with a reduction in evoked potential recovery.
Clinical application of hyperbaric oxygenation in the treatment of acute cerebral damage.
TLDR
This study selected patients suffering from neurological disorders subsequent to the postoperative course of a brain tumor, cerebrovascular disease, or cerebral ischemia for treatment in a hyperbaric chamber designed to operate at high pressure and large enough to accommodate the attendant staff and essential monitoring and therapeutic equipment.
Normobaric hyperoxia--induced improvement in cerebral metabolism and reduction in intracranial pressure in patients with severe head injury: a prospective historical cohort-matched study.
TLDR
The hypothesis that normobaric hyperoxia in patients with severe TBI improves the indices of brain oxidative metabolism is supported.
TREATMENT OF FOCAL CEREBRAL ISCHEMIA WITH HYPERBARIC OXYGEN
TLDR
An acute ischemia lesion of the bra in implies a rapid fall to zero of the oxygen tension within central par t s of t h e lesion, and measures which tend to ameliorate circulation anti oxygenation may diminish the final consequences of thc lesion.
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