Hyperbaric oxygen and chemical oxidants stimulate CO2/H+-sensitive neurons in rat brain stem slices.

@article{Mulkey2003HyperbaricOA,
  title={Hyperbaric oxygen and chemical oxidants stimulate CO2/H+-sensitive neurons in rat brain stem slices.},
  author={Daniel K Mulkey and Richard A. Henderson and Robert W. Putnam and Jay B. Dean},
  journal={Journal of applied physiology},
  year={2003},
  volume={95 3},
  pages={910-21}
}
Hyperoxia, a model of oxidative stress, can disrupt brain stem function, presumably by an increase in O2 free radicals. Breathing hyperbaric oxygen (HBO2) initially causes hyperoxic hyperventilation, whereas extended exposure to HBO2 disrupts cardiorespiratory control. Presently, it is unknown how hyperoxia affects brain stem neurons. We have tested the hypothesis that hyperoxia increases excitability of neurons of the solitary complex neurons, which is an important region for cardiorespiratory… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 35 extracted citations

Therapeutic ketosis with ketone ester delays central nervous system oxygen toxicity seizures in rats.

American journal of physiology. Regulatory, integrative and comparative physiology • 2013
View 1 Excerpt

Cytokines and resistive breathing

Human Physiology • 2012
View 1 Excerpt

References

Publications referenced by this paper.
Showing 1-10 of 69 references

Oxidative damage in the guinea pig hippocampal slice.

Free radical biology & medicine • 1989
View 4 Excerpts
Highly Influenced

Pressure ( 4 ATA) increases membrane conductance and firing rate in the rat solitary complex

DK Mulkey, RA IIIHenderson, RW Putnam, JB. Dean
J Appl Physiol • 2003
View 6 Excerpts
Highly Influenced

Reactive oxygen species and neuronal function

CC Colton, DL Gilbert
New York: Kluwer/ Plenum, • 1999
View 9 Excerpts
Highly Influenced

Chemistry of reactive oxygen species

RE Huie, P. Neta
Reactive Oxygen Species in Biological Systems . An Interdisciplinary Approach , edited by Gilbert DL and Colton CA • 1999
View 4 Excerpts
Highly Influenced

Effects of hyperbaric oxygen on heart, brain, and lung functions in rat.

Undersea biomedical research • 1982
View 6 Excerpts
Highly Influenced

Hyperoxic hyperventilation in carotid-deafferented cats.

Respiration physiology • 1975
View 10 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…