Hyperbaric oxygen and aerobic exercise in the long-term treatment of fibromyalgia: A narrative review.

  title={Hyperbaric oxygen and aerobic exercise in the long-term treatment of fibromyalgia: A narrative review.},
  author={Kholoud M. El-Shewy and Ahmad Kunbaz and Mohamed M. Gad and Muneer J. Al-Husseini and Anas M. Saad and Yasser Sammour and Mohamed M. Abdel-Daim},
  journal={Biomedicine \& pharmacotherapy = Biomedecine \& pharmacotherapie},
Comparative study of the effectiveness of a low-pressure hyperbaric oxygen treatment and physical exercise in women with fibromyalgia: randomized clinical trial
Low-pressure HBOT and physical exercise improve pressure pain threshold, endurance and functional capacity, as well as physical performance, in women with FM.
Evaluation of a Hyperbaric Oxygen Therapy Intervention in Individuals with Fibromyalgia.
HBOT appears to be feasible and safe for individuals with FM and is also associated with improved global functioning, reduced symptoms of anxiety and depression, and improved quality of sleep that was sustained at 3-month follow-up assessment.
The Role of Vitamin D in the Management of Chronic Pain in Fibromyalgia: A Narrative Review.
Vitamin D supplementation is inexpensive, has minimal side effects, and can benefit FM patients regardless of its efficacy in pain control, and high-quality studies are warranted to fully elucidate the potential of vitamin D to manage chronic pain in FM.
Comparison of Drug and Non-Drug Treatment Options of Fibromyalgia
The challenge of achieving adequate pain control without adverse side effects further compounds the problem and provides rationale for seeking complementary medicine and non-medicine alternatives.
Fibromyalgia: Recent Advances in Diagnosis, Classification, Pharmacotherapy and Alternative Remedies
  • M. Maffei
  • Medicine, Psychology
    International journal of molecular sciences
  • 2020
The purpose of this review is to summarize the recent advances in classification criteria and diagnostic criteria for FM as well as to explore pharmacotherapy and the use of alternative therapies including the useof plant bioactive molecules.
BMI but not age and sex negatively impact on the outcome of pharmacotherapy in fibromyalgia: a systematic review
A higher BMI is negatively associated with a favorable outcome in patients with fibromyalgia regardless of the pharmacological approach, the association with sex and age remains controversial.
Effect of Hyperbaric Therapy on Fibromyalgia Symptoms and Cerebral Blood Flow Abnormality
  • Medicine
  • 2019
Cerebral Blood Flow Abnormality Lelli L1*, Nieri A1, Tanasi P2, De Fina L2, Piazzini M3, Sotgia B1, Tosti Balducci M1 and Grechi M4 1Nuclear Medicine Unit, Department of Radiology, AUSL Toscana


Hyperbaric Oxygen Therapy Can Diminish Fibromyalgia Syndrome – Prospective Clinical Trial
HBOT in both groups led to significant amelioration of all FMS symptoms, with significant improvement in life quality, and shows that HBOT can induce neuroplasticity and significantly rectify abnormal brain activity in pain related areas of FMS patients.
Exercise in fibromyalgia and related inflammatory disorders: known effects and unknown chances.
An elevated "inflammatory status" in the FM syndrome is confirmed and the hypothesis that the benefits of exercise in FM patients are mediated, at least in part, by its anti-inflammatory effects is strengthened.
A New Treatment Modality for Fibromyalgia Syndrome: Hyperbaric Oxygen Therapy
A randomized controlled study to evaluate the effect of hyperbaric oxygen therapy in FMS concludes that HBO therapy has an important role in managing FMS.
The efficacy of hyperbaric oxygen therapy in the management of chronic fatigue syndrome.
  • S. Akarsu, L. Tekin, M. Kıralp
  • Medicine, Psychology
    Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc
  • 2013
It is inferred that hyperbaric oxygen (HBO2) therapy decreases the severity of symptoms and increases the life quality of CFS patients and may be a new treatment modality for the management of C FS.
Hyperexcitability in fibromyalgia.
There is a state of central hyperexcitability in the nociceptive system in FM that can be revealed by excitation of intramuscular nocICEptors in a muscle with no spontaneous pain.
Hyperbaric oxygen in chronic cluster headaches: influence on serotonergic pathways.
In the subgroup treated with the placebo, no particular modifications on the number of attacks and of analgesic consumption as well as no change in the specific binding curve of serotonin to mononuclear cells were observed, whereas in the sub group treated with HBO2 the clinical effectiveness and the appearance of plateau in the binding curves indicated that the oxygen therapy could act through serotonergic pathways.
Hyperbaric oxygen therapy in chronic pain management
HBO may be beneficial if appropriate patients are selected, and HBO is a reliable method of treatment, however, physicians performing HBO must be aware of oxygen toxicity.
Effectiveness of Hyperbaric Oxygen Therapy in the Treatment of Complex Regional Pain Syndrome
In conclusion, HBO is an effective and well-tolerated method for decreasing pain and oedema and increasing the ROM in patients with CRPS.
The science of fibromyalgia.
Evidence suggests that both the ascending and descending pain pathways operate abnormally, resulting in central amplification of pain signals, analogous to the "volume control setting" being turned up too high.