Hyperbaric hydrogen therapy: a possible treatment for cancer

@article{Dole1975HyperbaricHT,
  title={Hyperbaric hydrogen therapy: a possible treatment for cancer},
  author={Malcolm Dole and F R Wilson and W P Fife},
  journal={Science},
  year={1975},
  volume={190},
  pages={152 - 154}
}
Hairless albino mice with squamous cell carcinoma were exposed to a mixture of 2.5 percent oxygen and 97.5 percent hydrogen at a total pressure of 8 atmospheres for periods up to 2 weeks in order to see if a free radical decay catalyzer, such as hydrogen, would cause a regression of the skin tumors. Marked aggression of the tumors was found, leading to the possibility that hyperbaric hydrogen therapy might also prove to be of significance in the treatment of other types of cancer. 
Atmospheric pressure effects on tumor growth: hypobaric anoxia and growth of a murine transplantable tumor.
TLDR
Life-span studies showed a maximum of 36% increase in longevity in the hypobaric pressure-exposed mice when compared to that of unexposed controls, and a special role for hypoxia, perhaps even in oncogenesis, is suggested.
Medical Application of Hydrogen in Hematological Diseases
TLDR
The clinical advances of hydrogen gas in hematological disorders are presented and it is proven that hydrogen is an important physiological regulatory factor with antioxidative, anti-inflammatory, and antiapoptotic effects.
Hydrogen-rich water exerts anti-tumor effects comparable to 5-fluorouracil in a colorectal cancer xenograft model
TLDR
Administration of HRW, with or without 5-FU, may serve as a therapeutic for treating CRC, which significantly reduced tumor weight and size, as well as reduced collagen deposition and the degree of fibrosis, while further increasing OS and decreasing AA compared to administration of5-FU alone.
Discussion: Protective Effect of Hydrogen Gas Inhalation on Muscular Damage Using a Mouse Hindlimb Ischemia-Reperfusion Injury Model.
TLDR
In conclusion, inhaled hydrogen gas inhalation resulted in significant improvement in the histologic appearance of skeletal muscle following ischemia-reperfusion injury, noting decreased areas of necrosis and of polymorphonuclear cell infiltration.
Hydrogen as a New Class of Radioprotective Agent
TLDR
Encouraging results suggested that H2 represents a potentially novel preventative strategy for radiation-induced oxidative injuries and administration of hydrogen-rich solution (physiological saline/pure water/other solutions saturated with H2) may be more practical in daily life and more suitable for daily consumption.
Magnesium galvanic cells produce hydrogen and modulate the tumor microenvironment to inhibit cancer growth
TLDR
By decorating platinum on the surface of Mg rods, a Mg-based galvanic cell (MgG), which allows the continuous generation of H2 in an aqueous environment due to galvanic-cell-accelerated water etching of MG, suggests that the galvanic cells for hydrogen therapy based on implantable metals may be a safe and effective cancer treatment.
Molecular hydrogen and radiation protection
TLDR
The protective effect of H2 in irradiated cells and mice for the first time is reported, and encouraging results suggested that H2 has a potential as a radioprotective agent with efficacy and non-toxicity.
Inhalation of hydrogen gas attenuates cisplatin-induced ototoxicity via reducing oxidative stress.
A possible prevention strategy of radiation pneumonitis: Combine radiotherapy with aerosol inhalation of hydrogen-rich solution
  • Yunhai Chuai, Luqian Zhao, J. Cai
  • Medicine, Biology
    Medical science monitor : international medical journal of experimental and clinical research
  • 2011
TLDR
It is hypothesize that a treatment combining radiotherapy with aerosol inhalation of a hydrogen-rich solution may be an effective and novel prevention strategy for radiation pneumonitis (hydrogen is explosive, while a hydrogen -rich solution such as physiological saline saturated with molecular hydrogen is safer).
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