Hyperbaric ethanol antagonism: role of temperature, blood and brain ethanol concentrations.

@article{Malcolm1982HyperbaricEA,
  title={Hyperbaric ethanol antagonism: role of temperature, blood and brain ethanol concentrations.},
  author={R. Malcolm and Ronald L. Alkana},
  journal={Pharmacology, biochemistry, and behavior},
  year={1982},
  volume={16 2},
  pages={341-6}
}
Three studies investigated the mechanism of hyperbaric ethanol antagonism. C57 Bl/6j mice were injected intraperitoneally with 3.6 g/kg ethanol and were exposed to 1-12 atmospheres absolute (ATA) helium-oxygen or to 1 ATA air at temperatures that offset the cooling effects of helium or helium and ethanol. Hyperbaric treatment significantly reduced sleep-time and increased wake-up brain ethanol concentrations compared to temperature matched controls. Treatment with 12 ATA helium-oxygen increased… CONTINUE READING