Hyperbaric Oxygen for Carbon Monoxide Poisoning

@article{Buckley2005HyperbaricOF,
  title={Hyperbaric Oxygen for Carbon Monoxide Poisoning},
  author={Nicholas Alan Buckley and Geoffrey K. Isbister and Barrie J Stokes and David N Juurlink},
  journal={Toxicological Reviews},
  year={2005},
  volume={24},
  pages={75-92}
}
Poisoning with carbon monoxide (CO) is an important cause of unintentional and intentional injury worldwide. Hyperbaric oxygen (HBO) enhances CO elimination and has been postulated to reduce the incidence of neurological sequelae. These observations have led some clinicians to use HBO for selected patients with CO poisoning, although there is considerable variability in clinical practice.This article assesses the effectiveness of HBO compared with normobaric oxygen (NBO) for the prevention of… 
Impact of Hyperbaric Oxygen Therapy on Subsequent Neurological Sequelae Following Carbon Monoxide Poisoning
TLDR
The risk for NS was higher in patients with COP who received HBOT than in those who did not, even after considering the possible impact of longer observation periods on survivors.
In Reply: “Single Versus Multiple Hyperbaric Sessions for Carbon Monoxide Poisoning in a Murine Model”
TLDR
Whether there is a difference between one versus multiple HBO sessions for the prevention of delayed neurologic sequelae (DNS) due to CO poisoning is sought in a mouse model and there was no difference between groups treated with either one or three HBO sessions.
Update on hyperbaric oxygen therapy in burn treatment
Hyperbaric oxygen therapy (HBOT) has been shown to improve tissue hypoxia, neovascularization and ischemia reperfusion injury and reduce pathologic inflammation in various clinical settings and was
Carbon monoxide: an old poison with a new way of poisoning.
TLDR
Two events of carbon monoxide (CO) poisoning, which spread out through ventilation pipes to kill or injure neighbors, are presented, which were determined to be due to obstructions at the openings of ventilation pipes.
Hemorheological changes in cerebral circulation of rabbits with acute carbon monoxide poisoning.
TLDR
The results suggest that the changes in hemorheology participate in the development of acute CO poisoning, which may play a role in delayed encephalopathy after acuteCO poisoning.
An Evidence-Based Approach To Pediatric Carbon Monoxide Poisoning
TLDR
Evidence suggesting that CO poisoning should be considered in the differential diagnosis of pediatric patients with nonspecific complaints is examined, and the use of carboxyhemoglobin levels to determine severity of CO exposure is reviewed.
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References

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TLDR
Patients who manifest signs of serious intoxication should be considered candidates for hyperbaric oxygen therapy (HBO) in addition to other appropriate supportive and intensive care, and any patient who has suffered an interval of unconsciousness warrants HBO therapy.
Acute carbon monoxide poisoning. Risk of late sequelae and treatment by hyperbaric oxygen.
TLDR
In this opinion, HBO should be used on much wider indications than is usual, not only because of the rapid relief from symptoms it provides but mainly because it may prevent severe delayed sequelae.
Carbon monoxide poisoning: interpretation of randomized clinical trials and unresolved treatment issues.
TLDR
The most recent and best-designed randomized controlled clinical trial, performed in Salt Lake City, supports the efficacy of HBO2 in severe acute CO poisoning in accordance with scientific rationale and clinical experience.
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TLDR
Three hyperbaric-oxygen treatments within a 24-hour period appeared to reduce the risk of cognitive sequelae 6 weeks and 12 months after acute carbon monoxide poisoning.
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TLDR
Hyperbaric oxygen therapy facilitates the rapid removal of carbon monoxide from the hemoglobin and cytochrome systems while reoxygenating compromised tissues, and it can be an effective treatment in reducing mortality and morbidity.
Hyperbaric oxygen in carbon monoxide poisoning
TLDR
In conclusion, there was no evidence that delay to treatment might have explained the lack of benefit of hyperbaric oxygen, and analyses suggest that the results were not biased by cluster randomisation.
A prospective, randomized clinical trial comparing two hyperbaric treatment protocols for carbon monoxide poisoning.
TLDR
It is feasible to randomize CO-poisoned patients to different hyperbaric treatment protocols but determination of differences in efficacy between treatment protocols will require a large multicenter trial with the use of detailed neurocognitive testing.
Hyperbaric oxygen in carbon monoxide poisoning
There is little dispute that carbon monoxide poisoning is common: in the United States it produces an estimated 40 000 emergency department visits each year,1 and the accompanying editorial outlines
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