Hyperammonemic encephalopathy after adjunction of phenobarbital to chronic topiramate and oxcarbazepine therapy


There is limited information regarding the risk of increasing ammonia blood levels after the administration of (AEDs) other than valproic acid (VPA). A 23-year-old man was admitted in a first intensive care unit (ICU) for iterative generalized seizures. Epilepsy was diagnosed at the age of 3, without any clear etiology. His current antiepileptic therapy… (More)
DOI: 10.1007/s13760-015-0487-z

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