Hyperammonemia in review: pathophysiology, diagnosis, and treatment

  title={Hyperammonemia in review: pathophysiology, diagnosis, and treatment},
  author={Ari Auron and Patrick D. Brophy},
  journal={Pediatric Nephrology},
Ammonia is an important source of nitrogen and is required for amino acid synthesis. It is also necessary for normal acid-base balance. When present in high concentrations, ammonia is toxic. Endogenous ammonia intoxication can occur when there is impaired capacity of the body to excrete nitrogenous waste, as seen with congenital enzymatic deficiencies. A variety of environmental causes and medications may also lead to ammonia toxicity. Hyperammonemia refers to a clinical condition associated… CONTINUE READING
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