Hyperammonemia following allogeneic bone marrow transplantation

@article{Tse1991HyperammonemiaFA,
  title={Hyperammonemia following allogeneic bone marrow transplantation},
  author={Nielson Tse and Stephen D. Cederbaum and John A. Glaspy},
  journal={American Journal of Hematology},
  year={1991},
  volume={38}
}
Hyperammonemia is a rare and serious complication of intensive cytotoxic chemotherapy. We report the case of a patient who developed profound idiopathic hyperammonemia following bone marrow transplantation for chronic myelogenous leukemia. Despite rapid institution of hemodialysis, sodium benzoate, and the experimental agent sodium phenylacetate, the patient ultimately succumbed to complications of this metabolic derangement. The literature is reviewed, and recommendations for an approach to… 

Hyperammonemia after high-dose chemotherapy and stem cell transplantation

A patient with multiple myeloma who suffered from hyperammonemia after a second stem cell autograft is reported, with rapid recognition and treatment of the syndrome, the patient fully recovered.

Idiopathic hyperammonaemia syndrome following allogeneic peripheral blood progenitor cell transplantation (allo-PBPCT)

An idiopathic hyperammonaemia syndrome has been reported in, and following chemotherapy for, various haematological malignancies as well as following bone marrow transplantation, and a further case associated with an allogeneic peripheral blood progenitor cell transplant is described.

Transient Hyperammonemic Encephalopathy in a Child with Relapsed Acute Lymphoblastic Leukemia and Severe Tumor Lysis Syndrome

This case elucidates the diagnostic dilemma in children undergoing initiation of chemotherapy and developing severe disorders of qualitative and quantitative consciousness in the presence of hyperammonemia (HA) and lactic acidosis and reminds clinicians to check for HA in children with tumor lysis syndrome and acute neurological deterioration.

Hyperammonemia encephalopathy: An important cause of neurological deterioration following chemotherapy

Optimal management remains to be formally established, and the critical step is increased awareness of the syndrome by measurement of plasma ammonium levels in patients with neurological symptoms, leading to early diagnosis and the prompt implementation of therapy.

Hyperammonemic encephalopathy after chemotherapy. Survival after treatment with sodium benzoate and sodium phenylacetate.

A 16-year-old boy had hyperammonemia and encephalopathy develop after high-dose chemotherapy for acute lymphoblastic leukemia. He was treated successfully with the ammonia-trapping agents sodium

Neurological Complications of Hematopoietic Stem Cell Transplantation

This chapter summarizes the disorders affecting the nervous system associated with hematopoietic stem cell transplantation.

Neurologic Complications of Hematopoietic Stem Cell Transplantation

HSCT is now a common procedure to treat hematologic malignant disorders thought to be largely incurable and has potential use for a number of solid neoplasms and non-neoplastic disorders.

Idiopathic hyperammonemia in a patient with total pancreatectomy and islet cell transplantation.

It is proposed that malnutrition following total pancreatectomy resulting in repressed urea cycle enzyme synthesis may have predisposed for this hyperammonemia.

Idiopathic hyperammonemia following high-dose chemotherapy

The case of a 52-year-old woman with locally advanced HER2þ breast cancer and extensive breast and axillary involvement after preoperative chemotherapy with anthracyclines and taxanes, who was enrolled onto a phase II study of a novel high-dose regimen of trastuzumab/docetaxel/melphalan/carboplatin is reported here.

Unexplained Fatal Hyperammonemia in a Patient With New Diagnosis of Acute Monoblastic Leukemia

A fatal case of idiopathic hyperammonemia that was detected only nine days after induction chemotherapy in a 22-year-old man with no liver pathology or other risks for hyper ammonemia, shows that critical hyperam monemia can occur quickly after chemotherapy induction and that strategies for preventing a rise in plasma ammonia are necessary.

References

SHOWING 1-5 OF 5 REFERENCES

Reye's syndrome: Current concepts

What factors (NH3, free fatty acids and dicarboxylic acids) may be implicated in the pathogenesis of the CNS disease with the hopes of devising strategies for more effective treatment of encephalopathy and its attendant morbidity and mortality should be delineated.

Automated enzymatic assay for plasma ammonia.

An enzymatic method for determining plasma ammonia with the Du Pont Automatic Clinical Analyzer (aca) is described, using the coenzyme NADPH (instead of NADH) in this aca procedure eliminates the lengthy pre-incubation otherwise required for endogenous dehydrogenase reactions.