Hyperammonemia following allogeneic bone marrow transplantation

@article{Tse1991HyperammonemiaFA,
  title={Hyperammonemia following allogeneic bone marrow transplantation},
  author={Nielson Tse and Stephen D Cederbaum and John A. Glaspy},
  journal={American Journal of Hematology},
  year={1991},
  volume={38}
}
Hyperammonemia is a rare and serious complication of intensive cytotoxic chemotherapy. We report the case of a patient who developed profound idiopathic hyperammonemia following bone marrow transplantation for chronic myelogenous leukemia. Despite rapid institution of hemodialysis, sodium benzoate, and the experimental agent sodium phenylacetate, the patient ultimately succumbed to complications of this metabolic derangement. The literature is reviewed, and recommendations for an approach to… Expand
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References

SHOWING 1-5 OF 5 REFERENCES
Syndrome of idiopathic hyperammonemia after high-dose chemotherapy: review of nine cases.
TLDR
Because neurologic function can deteriorate rapidly, early recognition of this disorder and close monitoring of the patient's neurologic status are critical. Expand
Reye's syndrome: Current concepts
TLDR
What factors (NH3, free fatty acids and dicarboxylic acids) may be implicated in the pathogenesis of the CNS disease with the hopes of devising strategies for more effective treatment of encephalopathy and its attendant morbidity and mortality should be delineated. Expand
Automated enzymatic assay for plasma ammonia.
TLDR
An enzymatic method for determining plasma ammonia with the Du Pont Automatic Clinical Analyzer (aca) is described, using the coenzyme NADPH (instead of NADH) in this aca procedure eliminates the lengthy pre-incubation otherwise required for endogenous dehydrogenase reactions. Expand