Hyperalgesia induced by spinal and peripheral hydrogen sulfide: Evidence for involvement of Ca<ce:inf loc=post>v</ce:inf>3.2 T-type calcium channels

@article{Maeda2009HyperalgesiaIB,
  title={Hyperalgesia induced by spinal and peripheral hydrogen sulfide: Evidence for involvement of Ca<ce:inf loc=post>v</ce:inf>3.2 T-type calcium channels},
  author={Yumi Maeda and Yuka Aoki and Fumiko Sekiguchi and Maho Matsunami and Atsufumi Kawabata},
  journal={Pain},
  year={2009},
  volume={142},
  pages={127-132}
}
Hydrogen sulfide (H2S), a gasotransmitter, facilitates membrane currents through T-type Ca2+ channels, and intraplantar (i.pl.) administration of NaHS, a donor of H2S, causes prompt hyperalgesia in rats. In this context, we asked whether intrathecal (i.t.) administration of NaHS could mimic the hyperalgesic effect of i.pl. NaHS in rats, and then examined if Cav3.2 isoform of T-type Ca2+ channels contributed to the pro-nociceptive effects of i.t. and i.pl. NaHS. Either i.t. or i.pl… CONTINUE READING

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