Hyperalgesia in an immobilized rat hindlimb: effect of treadmill exercise using non-immobilized limbs.

@article{Chuganji2015HyperalgesiaIA,
  title={Hyperalgesia in an immobilized rat hindlimb: effect of treadmill exercise using non-immobilized limbs.},
  author={Sayaka Chuganji and J. Nakano and Yuki Sekino and Yohei Hamaue and Junya Sakamoto and Minoru Okita},
  journal={Neuroscience letters},
  year={2015},
  volume={584},
  pages={66-70}
}
Cast immobilization of limbs causes hyperalgesia, which is a decline of the threshold of mechanical and thermal mechanical stimuli. The immobilization-induced hyperalgesia (IIH) can disturb rehabilitation and activities of daily living in patients with orthopedic disorders. However, it is unclear what therapeutic and preventive approaches can be used to alleviate IIH. Exercise that activates the descending pain modulatory system may be effective for IIH. The purpose of this study was to… CONTINUE READING