Hyperalgesia and opioid switching

@article{Mercadante2005HyperalgesiaAO,
  title={Hyperalgesia and opioid switching},
  author={S. Mercadante and E. Arcuri},
  journal={American Journal of Hospice and Palliative Medicine},
  year={2005},
  volume={22},
  pages={291 - 294}
}
Opioids, intended to abolish pain, can unexpectedly produce hyperalgesia, particularly during rapid opioid escalation. Opioid switching could be a therapeutic option in a condition of opioid-induced tolerance or hyperalgesia, but conversion ratios between opioids are difficult to apply in this context and require strict surveillance and expertise. This situation is challenging, because the rapid escalation of opioid doses, possibly due to the development of opioid-induced tolerance, can cause… Expand
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