Hyperalgesia and allodynia induced by intrathecal (RS)-dihydroxyphenylglycine in rats.

  title={Hyperalgesia and allodynia induced by intrathecal (RS)-dihydroxyphenylglycine in rats.},
  author={Kim Fisher and Terence J. Coderre},
  volume={9 6},
To investigate the role of Group I mGluRs in allodynia and hyperalgesia, we examined the behavioural responses of rats to noxious and non-noxious mechanical and thermal stimuli following intrathecal (i.t.) treatment (25 nmol) with the selective mGluR1/5 agonist, (RS)-dihydroxyphenylglycine ((RS)-DHPG). (RS)-DHPG administration produced a persistent decrease in response latency on a 48 degrees C hotplate, a reduction in the 50% response threshold to von Frey hairs, and an increase in responses… CONTINUE READING

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