Hyperalgesia: An Emerging Iatrogenic Syndrome

  title={Hyperalgesia: An Emerging Iatrogenic Syndrome},
  author={Sebastiano L Mercadante and P. Mart{\'i}nez Ferrera and Patrizia Villari and Edoardo Arcuri},
  journal={Journal of pain and symptom management},
  volume={26 2},
Clinical reports suggest that opioids, intended to abolish pain, can unexpectedly produce hyperalgesia. This paradoxical effect may be mechanistically related to tolerance induced by increasing doses of opioids. Two case reports illustrate a syndrome characterized by increasing pain pursued by escalating opioid doses, which results in a worsening of the clinical picture. Several experimental data may help explain the course of this challenging clinical condition. In escalating opioid doses… CONTINUE READING


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