Hyperadrenocorticism and food restriction-induced life extension in the rat: evidence for divergent regulation of pituitary proopiomelanocortin RNA and adrenocorticotropic hormone biosynthesis.

@article{Han1995HyperadrenocorticismAF,
  title={Hyperadrenocorticism and food restriction-induced life extension in the rat: evidence for divergent regulation of pituitary proopiomelanocortin RNA and adrenocorticotropic hormone biosynthesis.},
  author={E S Han and Nancy Levin and N Bengani and Jaeda L. Roberts and Y Suh and Katarzyna Karelus and James F. Nelson},
  journal={The journals of gerontology. Series A, Biological sciences and medical sciences},
  year={1995},
  volume={50 5},
  pages={
          B288-94
        }
}
  • E. Han, N. Levin, J. Nelson
  • Published 1 September 1995
  • Biology, Medicine
  • The journals of gerontology. Series A, Biological sciences and medical sciences
The increased diurnal elevation of plasma corticosterone (B) induced by food restriction (FR) may play a role in the life span extension of FR. We investigated whether FR alters adrenocorticotropic hormone (ACTH) and proopiomelanocortin (POMC) mRNA levels in plasma and anterior pituitary (AP), since these molecules both regulate and can be suppressed by B. Measurements were made in 3-month-old male Fischer 344 rats that had been ad libitum (AL) or FR (60% of AL calories) since 6 weeks of age… 
Adrenocortical responsiveness to adrenocorticotropic hormone is enhanced in chronically food-restricted rats.
TLDR
The results indicate that enhanced adrenocortical responsiveness to ACTH plays a major role in the hyperadrenocorticals state of chronically FR rats.
Food restriction enhances endogenous and corticotropin-induced plasma elevations of free but not total corticosterone throughout life in rats.
TLDR
It is shown that the FR-enhanced adrenal response of total B to ACTH disappears with age but that the enhanced response of free B is maintained and the effect of FR on patterns of endogenous total and free diurnal B in these three age groups paralleled the ACTH-response data.
The effect of chronic food restriction on immunopositive ACTH cells in peripubertal female rats.
TLDR
It is concluded that chronic FR is a systemic stressor in young females, capable to stimulate the HPA axis, probably as a result of IL-6 action.
Food Restriction Differentially Affects Pituitary Hormone mRNAs throughout the Adult Life Span of Male F344 Rats
TLDR
Many of these changes in gene expression corroborate previously reported hormonal changes in FR rodents and mutant mice with extended life spans, and thus provide further support for the hypothesis that an altered hormonal milieu contributes to the antiaging effects of food restriction.
Food Restriction Differentially Affects mRNAs Encoding the Major Anterior Pituitary Tropic Hormones
  • E. HanD. LuJ. Nelson
  • Biology
    The journals of gerontology. Series A, Biological sciences and medical sciences
  • 1998
TLDR
It is revealed that FR differentially affects pituitary tropic hormone mRNA levels within weeks after onset of FR, and these results are consistent with a role for neuroendocrine alterations in the initiation of adaptive cellular responses to FR.
Nutrient-Gene Expression Food Restriction Differentially Affects Pituitary Hormone mRNAs throughout the Adult Life Span of Male F 344 Rats 1 , 2
TLDR
Many of these changes in gene expression corroborate previously reported hormonal changes in FR rodents and mutant mice with extended life spans, and thus provide further support for the hypothesis that an altered hormonal milieu contributes to the antiaging effects of food restriction.
Food Restriction, Hormones, Genes and Aging
TLDR
The results support the importance of altered insulin signaling in mediating the effects of GH on longevity and suggest that ACTH and glucocorticoids may have anti-aging actions.
Non-Invasive Measurement of Corticosterone in Food Restricted Rats
TLDR
Although it appeared that ACTH induced an increase in FCM in FR and control, only the latter reached statistical significance, so FCM might be better suited for quantifying chronic rather than acute changes in CORT.
...
...