• DOI:10.1148/RADIOLOGY.210.2.R99FE06519
• Corpus ID: 16747541

Hyperacute stroke: simultaneous measurement of relative cerebral blood volume, relative cerebral blood flow, and mean tissue transit time.

@article{Sorensen1999HyperacuteSS,
  title={Hyperacute stroke: simultaneous measurement of relative cerebral blood volume, relative cerebral blood flow, and mean tissue transit time.},
  author={A. Gregory Sorensen and William A Copen and Leif Ostergaard and Ferdinando Buonanno and R. Gilberto Gonzalez and Guy A. Rordorf and Bruce R. Rosen and Lee H. Schwamm and Robert M. Weisskoff and Walter J. Koroshetz},
  journal={Radiology},
  year={1999},
  volume={210 2},
  pages={
          519-27
        }
}

• A. Sorensen, W. Copen, +7 authors W. Koroshetz
• Published 1 February 1999
• Medicine
• Radiology

PURPOSE
To investigate additional information provided by maps of relative cerebral blood flow in functional magnetic resonance (MR) imaging of human hyperacute cerebral ischemic stroke.

MATERIALS AND METHODS
Diffusion-weighted and hemodynamic MR imaging were performed in 23 patients less than 12 hours after the onset of symptoms. Maps of relative cerebral blood flow and tracer mean tissue transit time were computed, as were maps of apparent diffusion and relative cerebral blood volume. Acute lesion volumes on the maps were compared with follow-up imaging findings.

RESULTS
In 15 of 23 subjects (65%), blood flow maps revealed hemodynamic abnormalities not visible on blood volume maps. A mismatch between initial blood flow and diffusion findings predicted growth of infarct more often (12 of 15 subjects with infarcts that grew) than did a mismatch between initial blood volume and diffusion findings (eight of 15). However, lesion volumes on blood volume and diffusion maps correlated better with eventual infarct volumes (r > 0.90) than did those on blood flow and tracer mean transit time maps (r approximately 0.6), likely as a result of threshold effects. In eight patients, blood volume was elevated around the diffusion abnormality, suggesting a compensatory hemodynamic response.

CONCLUSION
MR imaging can delineate areas of altered blood flow, blood volume, and water mobility in hyperacute human stroke. Predictive models of tissue outcome may benefit by including computation of both relative cerebral blood flow and blood volume.