Hyperactivity and hyperconnectivity of the default network in schizophrenia and in first-degree relatives of persons with schizophrenia.

@article{WhitfieldGabrieli2009HyperactivityAH,
  title={Hyperactivity and hyperconnectivity of the default network in schizophrenia and in first-degree relatives of persons with schizophrenia.},
  author={Susan L. Whitfield-Gabrieli and Heidi W. Thermenos and Snezana Milanovic and Ming T. Tsuang and Stephen V Faraone and R. W. McCarley and Martha Elizabeth Shenton and Alan I. Green and Alfonso Nieto-Casta{\~n}{\'o}n and Peter LaViolette and Joanne D Wojcik and John D E Gabrieli and Larry J. Seidman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 4},
  pages={1279-84}
}
We examined the status of the neural network mediating the default mode of brain function, which typically exhibits greater activation during rest than during task, in patients in the early phase of schizophrenia and in young first-degree relatives of persons with schizophrenia. During functional MRI, patients, relatives, and controls alternated between rest and performance of working memory (WM) tasks. As expected, controls exhibited task-related suppression of activation in the default… CONTINUE READING
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Altered cortical thickness in adolescents and young adults at genetic risk for schizophrenia

  • LJ Seidman
  • Schizophr Bull
  • 2007
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