Hyperactive antifreeze protein from beetles

@article{Graham1997HyperactiveAP,
  title={Hyperactive antifreeze protein from beetles},
  author={Laurie A. Graham and Yih-Cherng Liou and Virginia K. Walker and Peter L. Davies},
  journal={Nature},
  year={1997},
  volume={388},
  pages={727-728}
}
We have purified a thermal hysteresis (antifreeze) protein, with up to 100 times the specific activity of fish antifreeze proteins, from the common yellow mealworm beetle, Tenebrio molitor. It is a threonine- and cysteine-rich protein, of relative molecular mass 8,400, composed largely of 12-amino-acid repeats. We estimate that a concentration of roughly 1 mg ml−1 of this protein can account for the 5.5 °C of thermal hysteresis found in Tenebrio larvae (Fig. 1). 
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