Hyperactive antifreeze protein from beetles

  title={Hyperactive antifreeze protein from beetles},
  author={L. Graham and Yih-Cherng Liou and V. Walker and P. Davies},
  • L. Graham, Yih-Cherng Liou, +1 author P. Davies
  • Published 1997
  • Chemistry, Medicine
  • Nature
  • We have purified a thermal hysteresis (antifreeze) protein, with up to 100 times the specific activity of fish antifreeze proteins, from the common yellow mealworm beetle, Tenebrio molitor. It is a threonine- and cysteine-rich protein, of relative molecular mass 8,400, composed largely of 12-amino-acid repeats. We estimate that a concentration of roughly 1 mg ml−1 of this protein can account for the 5.5 °C of thermal hysteresis found in Tenebrio larvae (Fig. 1). 
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