Hyperactive Human Glucocorticoid Receptor Isoforms and their Implications for the Stress Response.

@article{Lasker2015HyperactiveHG,
  title={Hyperactive Human Glucocorticoid Receptor Isoforms and their Implications for the Stress Response.},
  author={Michael V. Lasker and Stacey M. Leventhal and Debora Lim and Tajia L. Green and Kelly Tung and Kiho Cho and David G. Greenhalgh},
  journal={Shock},
  year={2015},
  volume={43 3},
  pages={228-32}
}
Glucocorticoids are indispensable therapeutic agents in diseases of inflammation, but their effectiveness in treating advanced septic shock has been inconsistent. Our understanding of the mechanisms causing this variability to steroid therapy remains limited. Previous studies in our laboratory have implicated human glucocorticoid receptor (hGR) polymorphisms as one of the likely reasons for this variability. We examined the effect of two single-nucleotide polymorphisms (SNPs) on the… CONTINUE READING