Hyper-osmotic stress induces volume change and calcium transients in chondrocytes by transmembrane, phospholipid, and G-protein pathways.

@article{Erickson2001HyperosmoticSI,
  title={Hyper-osmotic stress induces volume change and calcium transients in chondrocytes by transmembrane, phospholipid, and G-protein pathways.},
  author={Geoffrey R Erickson and Leonidas G. Alexopoulos and Farshid Guilak},
  journal={Journal of biomechanics},
  year={2001},
  volume={34 12},
  pages={1527-35}
}
Mechanical compression of cartilage is associated with a rise in the interstitial osmotic pressure, which can alter cell volume and activate volume recovery pathways. One of the early events implicated in regulatory volume changes and mechanotransduction is an increase of intracellular calcium ion ([Ca(2+)](i)). In this study, we tested the hypothesis that osmotic stress initiates intracellular Ca(2+) signaling in chondrocytes. Using laser scanning microscopy and digital image processing, [Ca(2… CONTINUE READING
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