Hyper-mitogenic drive coexists with mitotic incompetence in senescent cells

@inproceedings{Leontieva2012HypermitogenicDC,
  title={Hyper-mitogenic drive coexists with mitotic incompetence in senescent cells},
  author={Olga V. Leontieva and Felicia L Lenzo and Zoya N. Demidenko and Mikhail V. Blagosklonny},
  booktitle={Cell cycle},
  year={2012}
}
When the cell cycle is arrested, even though growth-promoting pathways such as mTOR are still active, then cells senesce. For example, induction of either p21 or p16 arrests the cell cycle without inhibiting mTOR, which, in turn, converts p21/p16-induced arrest into senescence (geroconversion). Here we show that geroconversion is accompanied by dramatic accumulation of cyclin D1 followed by cyclin E and replicative stress. When p21 was switched off, senescent cells (despite their loss of… CONTINUE READING

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Hypoxia suppresses conversion from proliferative arrest to cellular senescence.

Proceedings of the National Academy of Sciences of the United States of America • 2012
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