Hyper-methylation of the upstream CpG island shore is a likely mechanism of GPER1 silencing in breast cancer cells.

@article{Manjegowda2017HypermethylationOT,
  title={Hyper-methylation of the upstream CpG island shore is a likely mechanism of GPER1 silencing in breast cancer cells.},
  author={Mohan C. Manjegowda and Paridhi Gupta and Anil Mukund Limaye},
  journal={Gene},
  year={2017},
  volume={614},
  pages={
          65-73
        }
}
  • Mohan C. Manjegowda, Paridhi Gupta, Anil Mukund Limaye
  • Published in Gene 2017
  • Biology, Medicine
  • GPER1, also known as GPR30, is a novel seven-transmembrane G-protein coupled estrogen receptor that mediates both short-term (non-genomic) and long-term (genomic) effects of estrogen in target cells and tissues. A substantial body of work over the last two decades has highlighted its therapeutic or prognostic utility. However, the clinical data on the expression of GPER1 in breast tissue is ambiguous. Analysis of TCGA RNAseq data revealed significantly lower mean expression of GPER1 mRNA in… CONTINUE READING

    Create an AI-powered research feed to stay up to date with new papers like this posted to ArXiv

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 32 REFERENCES

    J

    • E. J. Filardo
    • a Quinn, K.I. Bland, a R. Frackelton, Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via transactivation of the epidermal growth factor receptor through release of HB-EGF., Mol. Endocrinol. 14
    • 2000
    VIEW 8 EXCERPTS
    HIGHLY INFLUENTIAL

    A

    • T. Ignatov, C. Weißenborn, A. Poehlmann, A. Lemke, A. Semczuk
    • Roessner, et al., GPER-1 expression decreases during breast cancer tumorigenesis., Cancer Invest. 31
    • 2013
    VIEW 5 EXCERPTS
    HIGHLY INFLUENTIAL

    P

    • X. Zhou, S. Wang, Z. Wang, X. Feng
    • Liu, X.-B. Lv, et al., Estrogen regulates Hippo signaling via GPER in breast cancer, J. Clin. Invest. 125
    • 2015
    VIEW 2 EXCERPTS

    A

    • C. Weißenborn, T. Ignatov
    • Poehlmann, A.K. Wege, S.D. Costa, A.C. Zenclussen, et al., GPER functions as a tumor suppressor in MCF-7 and SK-BR-3 breast cancer cells., J. Cancer Res. Clin. Oncol. 140
    • 2014

    G

    • Z. Mo, M. Liu, F. Yang, H. Luo, Z. Li
    • Tu, et al., GPR30 as an initiator of tamoxifen resistance in hormone-dependent breast cancer., Breast Cancer Res. 15
    • 2013
    VIEW 1 EXCERPT

    P

    • X. Rao, J. Evans, H. Chae, J. Pilrose, S. Kim
    • Yan, et al., CpG island shore methylation regulates caveolin-1 expression in breast cancer, Oncogene. 32
    • 2013

    Eliceiri, NIH Image to ImageJ: 25 years of image analysis

    • C. A. Schneider, K.W.W.S. Rasband
    • Nat. Methods
    • 2012
    VIEW 2 EXCERPTS

    J

    • D. C. Koboldt, R. S. Fulton, M. D. McLellan, H. Schmidt
    • Kalicki-Veizer, J.F. McMichael, et al., Comprehensive molecular portraits of human breast tumours, Nature. 490
    • 2012

    J

    • D. Sproul, C. Nestor
    • Culley, J.H. Dickson, J.M. Dixon, D.J. Harrison, et al., Transcriptionally repressed genes become aberrantly methylated and distinguish tumors of different lineages in breast cancer., Proc. Natl. Acad. Sci. U. S. A. 108
    • 2011