Hyper-immunoglobulin A in the hyperimmunoglobulinemia D syndrome.

  title={Hyper-immunoglobulin A in the hyperimmunoglobulinemia D syndrome.},
  author={Ina S. Klasen and Joop H C G{\"o}ertz and G A van de Wiel and Corry M. R. Weemaes and Jos W M van der Meer and Joost P. H. Drenth},
  journal={Clinical and diagnostic laboratory immunology},
  volume={8 1},
The hyperimmunoglobulinemia D syndrome (HIDS) is an autosomal recessive disorder characterized by recurrent febrile attacks with abdominal, articular, and skin manifestations. Apart from elevated immunoglobulin D (IgD) levels (>100 IU/ml), there are high IgA levels in the majority of cases. Mutations in the gene encoding mevalonate kinase constitute the molecular defect in HIDS. The cause of elevated IgA concentrations in HIDS patients remains to be elucidated. We studied the hyper-IgA response… CONTINUE READING


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Serum IgD in infants and children

  • A. Haraldsson, C.M.R. Weemaes, +4 authors I. S. Klasen
  • Scand., J. Immunol
  • 2000
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