Hyper-eosinophilia in granular acute B-cell lymphoblastic leukemia with myeloid antigen expression.

Abstract

Acute lymphoblastic leukemia with eosinophilia (ALLEo) is a rare but a distinctive clinical entity. Clinical features of idiopathic hyper-eosinophilic syndrome (HES) can be seen in patients with ALLEo. We report a 10-year-old girl, in whom HES was initially suspected but further investigation confirmed the diagnosis of acute B-cell lymphoblastic leukemia with myeloid antigen expression. Clinical response to chemotherapy was excellent with achievement of complete remission for 4 years. Serum interleukin-3 and -5 were elevated at presentation and normalized with disappearance of eosinophilia after induction therapy, supporting the reactive nature of eosinophilia in ALLEo. Hematologic malignancy should be considered in patients with hyper-eosinophilia, before attributing it to HES.

DOI: 10.1111/j.1442-200X.2011.03471.x

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Cite this paper

@article{Kobayashi2012HypereosinophiliaIG, title={Hyper-eosinophilia in granular acute B-cell lymphoblastic leukemia with myeloid antigen expression.}, author={Daisuke Kobayashi and Kazuhiro Kogawa and Kohsuke Imai and Toshio Tanaka and Akiko Sada and Shigeaki Nonoyama}, journal={Pediatrics international : official journal of the Japan Pediatric Society}, year={2012}, volume={54 4}, pages={543-6} }