Hyper- and hypo-induction of cytochrome P450 activities with Aroclor 1254 and 3-methylcholanthrene in Cyp1a2(-/-) mice.

@article{Barker2009HyperAH,
  title={Hyper- and hypo-induction of cytochrome P450 activities with Aroclor 1254 and 3-methylcholanthrene in Cyp1a2(-/-) mice.},
  author={Melissa L Barker and Laura B Hathaway and Dorinda D Arch and Mark L. Westbroek and James P. Kushner and John D. Phillips and Michael R. Franklin},
  journal={Chemico-biological interactions},
  year={2009},
  volume={182 2-3},
  pages={220-6}
}
The response of hepatic mono-oxygenase activities to Aroclor 1254 or 3-methylcholanthrene was investigated in wild-type and Cyp1a2(-/-) mice. Cytochrome P450 concentrations were similar in naïve Cyp1a2(-/-) and wild-type mice. There was no difference between naïve wild-type and Cyp1a2(-/-) animals in 7-ethoxyresorufin and 7-ethoxy-4-trifluoromethylcoumarin… CONTINUE READING