Hyper-activation of WNT/β-catenin signaling pathway mediates anti-tumor effects of histone deacetylase inhibitors in acute T lymphoblastic leukemia.

@article{Shao2012HyperactivationOW,
  title={Hyper-activation of WNT/β-catenin signaling pathway mediates anti-tumor effects of histone deacetylase inhibitors in acute T lymphoblastic leukemia.},
  author={Na Shao and Jie Zou and Jie Li and F. -X. Chen and Jianjian Dai and Xun Qu and Xiulian Sun and Dao-xin Ma and Chunyan Ji},
  journal={Leukemia & lymphoma},
  year={2012},
  volume={53 9},
  pages={1769-78}
}
Histone deacetylase inhibitors (HDACis) are promising agents for the treatment of acute T lymphoblastic leukemia (T-ALL). However, the underlying mechanisms remain to be elucidated. Based on a recent study showing that HDACis were able to modulate WNT/β-catenin signaling, we further investigated the influence of HDACis on WNT/β-catenin signaling in T-ALL cells and modulation of WNT/β-catenin signaling in mediating anti-leukemic effects of HDACis. Results from Western blotting… CONTINUE READING

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