Hyper IgM immunodeficiency. A primary dysfunction of B lymphocyte isotype switching.

@article{Levitt1983HyperII,
  title={Hyper IgM immunodeficiency. A primary dysfunction of B lymphocyte isotype switching.},
  author={Daniel Levitt and Patricia L. Haber and Kevin Rich and Max D. Cooper},
  journal={The Journal of clinical investigation},
  year={1983},
  volume={72 5},
  pages={
          1650-7
        }
}
Immunological evaluations (lymphocyte markers, B cell differentiation, T cell function) were performed on peripheral blood mononuclear cells from four individuals with hyper IgM immunodeficiency. Number, proportion, and proliferation of T lymphocytes and T lymphocyte subpopulations were relatively normal in affected individuals. The percentage and number of B cells expressing surface IgM and IgD were either normal or elevated in both blood and lymph nodes. However, surface IgG- and IgA-bearing… 
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TLDR
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