Hype about glucosamine

  title={Hype about glucosamine},
  author={Mark Adams},
  journal={The Lancet},
  • M. Adams
  • Published 31 July 1999
  • Medicine
  • The Lancet
Complementary and alternative medicine use by osteoporosis clinic patients
Patients attending osteoporosis clinics frequently use complementary and alternative medicine (CAM), and the predictors of use may fit into a socio-behavioral model that helps explain why people turn to CAM.
The study shows that the exposure level for the surgeons gets restricted when the patient is Obese, muscular and one having deformity of his knee, which means patient with knee recurvatum had better exposure level in Tkr via Subvastus approach.
Glucosamine sulphate-loaded distearoyl phosphocholine liposomes for osteoarthritis treatment: combination of sustained drug release and improved lubrication.
The experimental results indicated that the GAS-loaded DSPC liposomes could release GAS in a sustained manner while providing good lubrication in pure water (H2O) and phosphate buffered saline (PBS).
Structural characterization, molecular modification and hepatoprotective effect of melanin from Lachnum YM226 on acute alcohol-induced liver injury in mice.
The present findings recommend that Lachnum YM226 and GLM may be used as a prototype for the prevention of alcoholic liver injury.
Drug-Induced Hyperglycaemia and Diabetes
Clinicians should be aware of medications that may alter glycaemia, and efforts should be made to identify and closely monitor patients receiving drugs that are known to induce hyperglycaemia.
Effect of glucosamine sulfate on surface interactions and lubrication by hydrogenated soy phosphatidylcholine (HSPC) liposomes.
HSPC-SUVs with encapsulated GAS are stable upon shear at high compressions and provide very good lubrication when immersed both in pure water and physiological-level salt solutions (in the latter case, the liposomes are exceptionally stable and lubricious up to >400 atm).
Management of Type 2 diabetes mellitus in primary care
The aim of this thesis is to present the body of published work on an evaluation research study on the change in service delivery for people with type 2 diabetes, resulting in one peer reviewed report and five peer-reviewed papers published in international journals.
Glucosamine Salts: Resolving Ambiguities over the Market-Based Compositions
The neutral form of glucosamine, C6H13NO5, one the most effective and most widely used over-the-counter health supplements for the relief of osteoarthritis, is very unstable in air. It is marketed as
Role of glucosamine in the treatment for osteoarthritis
There is now a large, convergent body of evidence that glucosamine sulfate, given at a daily oral dose of 1,500 mg, is able to significantly reduce the symptoms of osteoarthritis in the lower limbs.


Biological Regulation of the Chondrocytes
The Different Types of Chondrocytes and Their Function In Vivo and the In Vitro Approach to the Study of Biological Regulation are presented.
Hexosamines and Insulin Resistance
Evidence for the possible role of this pathway in normal glucose homeostasis and disease is that the level of activity of the rate-limiting enzyme in hexosamine synthesis, glutamine:fructose-6-phosphate amidotransferase, is correlated with glucose disposal rates (GDRs) in normal humans and transgenic mice.
Discoordinate gene expression of aggrecan and type II collagen in experimental osteoarthritis.
Discoordinate gene expression of aggrecan and type II collagen is characteristic of early experimental OA, and it is speculated that it may contribute to its pathogenesis.
Role of glucosamine synthesis in the stimulation of TGF-alpha gene transcription by glucose and EGF.
It is found that, although EGF stimulates GFAT mRNA accumulation in MDA-MB-468 cells, this effect of EGF occurred several hours after TGF-alpha transcription increased, supporting the notion that glucose stimulation of T GF-alpha expression requires GFAT, but EGF stimulation does not.
Glucosamine induces insulin resistance in vivo by affecting GLUT 4 translocation in skeletal muscle. Implications for glucose toxicity.
Glucosamine is a potent inducer of insulin resistance in vivo by causing (at least in part) a defect intrinsic to GLUT 4 translocation and/or trafficking and a potential role for Glmn to cause glucose-induced insulin resistance (glucose toxicity).
Pharmacokinetics of glucosamine in the dog and in man.
The pharmacokinetics, organ distribution, metabolism and excretion of glucosamine were studied in the dog giving uniformly labelled [14C]-glucosamine (sulfate), i.v. or orally, in single doses, and the pattern of disappearance, metabolic transformation, tissue distribution andexcretion of the radioactivity are consistent with those found after i.V. administration.
Stimulation of proteoglycan production by glucosamine sulfate in chondrocytes isolated from human osteoarthritic articular cartilage in vitro.
Glucosamine sulfate did not affect DNA synthesis nor coll II production but caused a statistically significant stimulation of PG production by chondrocytes from human osteoarthritic cartilage cultured for up to 12 days in 3-dimensional cultures.