Hyoscine for clozapine-induced hypersalivation: a double-blind, randomized, placebo-controlled cross-over trial

@article{Segev2019HyoscineFC,
  title={Hyoscine for clozapine-induced hypersalivation: a double-blind, randomized, placebo-controlled cross-over trial},
  author={Aviv Segev and Anthony Evans and John Hodsoll and Eromona Whiskey and Rebecca Syed Sheriff and Sukhi S. Shergill and James Hunter MacCabe},
  journal={International Clinical Psychopharmacology},
  year={2019},
  volume={34},
  pages={101–107}
}
Clozapine is the only evidence-based antipsychotic for treatment-resistant schizophrenia. However, it has considerable side effects, limiting its usability and reducing patients’ adherence. One of the most common and distressing side effects is hypersalivation, which can be debilitating, stigmatizing and potentially dangerous through its association with aspiration pneumonia. There is a paucity of evidence guiding possible treatment strategies for hypersalivation. This study aims to examine the… 

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