Hyoscine Butylbromide

@article{Tytgat2012HyoscineB,
  title={Hyoscine Butylbromide},
  author={Guido N. J. Tytgat},
  journal={Drugs},
  year={2012},
  volume={67},
  pages={1343-1357}
}
Abdominal cramping and pain is a frequent problem in the adult population of Western countries, with an estimated prevalence of ≤30. [...] Key ResultTen placebo-controlled studies have evaluated the efficacy and safety of oral or rectal hyoscine butylbromide. Hyoscine butylbromide was considered beneficial in all of these trials, which supports its use in the treatment of abdominal pain caused by cramping.Expand
Ketorolac tromethamine improves the analgesic effect of hyoscine butylbromide in patients with intense cramping pain from gastrointestinal or genitourinary origin.
TLDR
Data indicate that the oral ketorolac/hyoscinebutylbromide mixture could be a better option than hyoscine butyl bromide alone in the treatment of some acute intense cramping painful conditions. Expand
Effect of hyoscine butyl-bromide on the duration of active phase of labor: A randomized-controlled trial.
TLDR
Hyoscine butyl-bromide was effective in shortening the duration of the active phase of labor and was also associated with significantly less postpartum blood loss. Expand
Efficacy of hyoscine butyl-bromide in shortening the active phase of labor: Systematic review and meta-analysis of randomized trials.
TLDR
Evaluating whether HBB is effective in decreasing the mean duration of the active phase of labor in primiparae and multiparae women found it to be an effective treatment. Expand
The pharmacokinetics of orally administered butylscopolamine in greyhound dogs
TLDR
Medication control of butylscopolamine's antispasmodic effect on the digestive tract is possible by setting screening limits based on the urinary and faecal drug levels as determined in this study. Expand
Anaphylaxis caused by butylscopolamine bromide: a case report
TLDR
Butylscopolamine has the potential to cause severe anaphylaxis; hence, identification of the causative agent is important to prevent recurrence of anaphYLaxis. Expand
The effect of hyoscine-N-butylbromide on pain perception during and after hysterosalpingography in infertile women: a systematic review and meta-analysis of randomised controlled trials.
TLDR
Good evidence is provided that prior administration of HBB is effective in reducing induced pain during and after HSG with tolerable side effects. Expand
Comparing hyoscine and drotaverine effects on colon in CT colonography
TLDR
It is concluded that drotaverine can be used as a means to facilitate colonic distension. Expand
Clinical Assessment of the Use of Propinox Hydrochloride and Scopolamine Hydrochloride in the Treatment of Abdominal Colic: A Retrospective, Comparative Study
TLDR
Both treatments demonstrated good efficacy and tolerability in the treatment of abdominal colic pain, in the population evaluated, indicating a therapeutic equivalence between propinox hydrochloride and scopolamine hydrochlorides. Expand
The noradrenergic agent reboxetine plus the antimuscarinic hyoscine butylbromide reduces sleep apnoea severity: a double‐blind, placebo‐controlled, randomised crossover trial
TLDR
It is found that reboxetine plus hyoscine butylbromide reduced OSA severity including overnight hypoxemia via increases in pharyngeal muscle responsiveness, improvements in respiratory control and airway collapsibility without changing the respiratory arousal threshold. Expand
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References

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TLDR
These therapeutic results, though far from perfect, show that the types of drug commonly used to treat IBS are of some value and may be additive in their effects. Expand
N-butyl hyoscine exerts local spasmolytic effect in the small and large bowel of the conscious dog.
TLDR
NBH present in the intestine, although poorly absorbed, exerts local spasmolytic action in conscious dogs provided with ileal or colonic Thiry fistulas in which motility was stimulated by intraluminal distension. Expand
Quaternary ammonium derivatives as spasmolytics for irritable bowel syndrome.
TLDR
Taking into consideration the published trials carried out with validated methodology in irritable bowel syndrome, cimetropium and otilonium are the best demonstrated drugs for the improvement in global assessment, pain and abdominal distension. Expand
Effects of oral cyclotropium bromide, hyoscine N-butylbromide and placebo on gastric emptying and antral motor activity in healthy man.
TLDR
In conclusion, cyclotropium bromide markedly inhibits gastric emptying and reduces antral contraction amplitude and hyoscine N-butylbromide differed significantly from placebo. Expand
Anticholinergic effects and passage through the intestinal wall of N‐butylhyoscine bromide
TLDR
Findings help to explain why enterally administered N‐butylhyoscine bromide exerts anti‐cholinergic effects on the gut without producing systemic actions. Expand
Placebo‐ and paracetamol‐controlled study on the efficacy and tolerability of hyoscine butylbromide in the treatment of patients with recurrent crampy abdominal pain
TLDR
To compare the efficacy and tolerability of oral hyoscine butylbromide with paracetamol, and their fixed combination against placebo in patients with recurrent crampy abdominal pain. Expand
The actions of atropine, tropenziline and N‐butyl hyoscine bromide on the isolated distal colon of the guinea‐pig: a comparison of their activities and mechanisms of action
TLDR
It is suggested that muscarinic receptors of the parasympathetic ganglia are involved in transmission of pelvic nerve impulses in guinea‐pig isolated distal colon. Expand
Observations on the efficacy of oral hyoscine N‐butyl bromide
TLDR
Hyoscine N‐butyl bromide (Buscopan) antagonized the spasmogenic action of acetylcholine on guinea‐pig isolated ileum and had intestinal antispasmodic activity in the anaesthetized cat after either parenteral or enteral administration. Expand
Meta‐analysis: the treatment of irritable bowel syndrome
TLDR
Evidence is weak to recommend the use of bulking agents in the treatment of irritable bowel syndrome with constipation, but antidepressants can be beneficial for patients with severe symptoms and loperamide can be recommended in painless diarrhoea. Expand
Treatment of pain symptoms in irritable bowel syndrome patients.
TLDR
Through a proper understanding of the diagnostic criteria, pathophysiology and treatment options, this disorder can be treated effectively in many patients. Expand
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