Hyoscine Butylbromide

  title={Hyoscine Butylbromide},
  author={Guido N. J. Tytgat},
  • G. Tytgat
  • Published 2012
  • Medicine, Biology
  • Drugs
Abdominal cramping and pain is a frequent problem in the adult population of Western countries, with an estimated prevalence of ≤30. [] Key ResultTen placebo-controlled studies have evaluated the efficacy and safety of oral or rectal hyoscine butylbromide. Hyoscine butylbromide was considered beneficial in all of these trials, which supports its use in the treatment of abdominal pain caused by cramping.

Ketorolac tromethamine improves the analgesic effect of hyoscine butylbromide in patients with intense cramping pain from gastrointestinal or genitourinary origin.

Data indicate that the oral ketorolac/hyoscinebutylbromide mixture could be a better option than hyoscine butyl bromide alone in the treatment of some acute intense cramping painful conditions.

Comparison of paracetamol and hyoscine-N-butylbromide in the treatment of abdominal pain and cramps due to acute gastroenteritis

HBB and paracetamol were used for symptomatic treatment in AGE patients presenting with abdominal pain and cramps and a significant reduction in pain andCramps was achieved in both patient groups.

Hyoscine butylbromide mode of action on bowel motility: From pharmacology to clinical practice.

This review is the result of the collaboration between a basic scientist and clinicians with the aim of providing an updated overview of the mechanisms of action of HBB and its clinical efficacy to guide not only use in clinical practice, but also future research.

Cardiovascular effects of hyoscine butylbromide in patients under general anaesthesia.

Hyoscine butylbromide generates positive effects on the heart rate and blood pressure of patients under general anaesthesia, representing a possible alternative in the management of intraoperative bradycardia.

The pharmacokinetics of orally administered butylscopolamine in greyhound dogs

Medication control of butylscopolamine's antispasmodic effect on the digestive tract is possible by setting screening limits based on the urinary and faecal drug levels as determined in this study.

Anaphylaxis caused by butylscopolamine bromide: a case report

Butylscopolamine has the potential to cause severe anaphylaxis; hence, identification of the causative agent is important to prevent recurrence of anaphYLaxis.

The effect of hyoscine-N-butylbromide on pain perception during and after hysterosalpingography in infertile women: a systematic review and meta-analysis of randomised controlled trials

Good evidence is provided that prior administration of HBB is effective in reducing induced pain during and after HSG with tolerable side effects.

Canadian Association of Gastroenterology (CAG) Position Statement on the Use of Hyoscine-n-butylbromide (Buscopan) During Gastrointestinal Endoscopy

The Clinical Affairs Committee of the Canadian Association of Gastroenterology conducted systematic reviews and applied the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach to develop recommendations for the use of Buscopan during GI endoscopy.



Treatment of irritable bowel syndrome with lorazepam, hyoscine butylbromide, and ispaghula husk.

These therapeutic results, though far from perfect, show that the types of drug commonly used to treat IBS are of some value and may be additive in their effects.

N-butyl hyoscine exerts local spasmolytic effect in the small and large bowel of the conscious dog.

NBH present in the intestine, although poorly absorbed, exerts local spasmolytic action in conscious dogs provided with ileal or colonic Thiry fistulas in which motility was stimulated by intraluminal distension.

Quaternary ammonium derivatives as spasmolytics for irritable bowel syndrome.

Taking into consideration the published trials carried out with validated methodology in irritable bowel syndrome, cimetropium and otilonium are the best demonstrated drugs for the improvement in global assessment, pain and abdominal distension.

Effects of oral cyclotropium bromide, hyoscine N-butylbromide and placebo on gastric emptying and antral motor activity in healthy man.

In conclusion, cyclotropium bromide markedly inhibits gastric emptying and reduces antral contraction amplitude and hyoscine N-butylbromide differed significantly from placebo.

Anticholinergic effects and passage through the intestinal wall of N‐butylhyoscine bromide

Findings help to explain why enterally administered N‐butylhyoscine bromide exerts anti‐cholinergic effects on the gut without producing systemic actions.

Placebo‐ and paracetamol‐controlled study on the efficacy and tolerability of hyoscine butylbromide in the treatment of patients with recurrent crampy abdominal pain

To compare the efficacy and tolerability of oral hyoscine butylbromide with paracetamol, and their fixed combination against placebo in patients with recurrent crampy abdominal pain.

The actions of atropine, tropenziline and N‐butyl hyoscine bromide on the isolated distal colon of the guinea‐pig: a comparison of their activities and mechanisms of action

It is suggested that muscarinic receptors of the parasympathetic ganglia are involved in transmission of pelvic nerve impulses in guinea‐pig isolated distal colon.

Observations on the efficacy of oral hyoscine N‐butyl bromide

Hyoscine N‐butyl bromide (Buscopan) antagonized the spasmogenic action of acetylcholine on guinea‐pig isolated ileum and had intestinal antispasmodic activity in the anaesthetized cat after either parenteral or enteral administration.

Meta‐analysis: the treatment of irritable bowel syndrome

Evidence is weak to recommend the use of bulking agents in the treatment of irritable bowel syndrome with constipation, but antidepressants can be beneficial for patients with severe symptoms and loperamide can be recommended in painless diarrhoea.

Treatment of pain symptoms in irritable bowel syndrome patients.

Through a proper understanding of the diagnostic criteria, pathophysiology and treatment options, this disorder can be treated effectively in many patients.