Hyoscine Butylbromide

@article{Tytgat2012HyoscineB,
  title={Hyoscine Butylbromide},
  author={Guido N. J. Tytgat},
  journal={Drugs},
  year={2012},
  volume={67},
  pages={1343-1357}
}
  • G. Tytgat
  • Published 2012
  • Medicine, Biology
  • Drugs
Abdominal cramping and pain is a frequent problem in the adult population of Western countries, with an estimated prevalence of ≤30. [] Key ResultTen placebo-controlled studies have evaluated the efficacy and safety of oral or rectal hyoscine butylbromide. Hyoscine butylbromide was considered beneficial in all of these trials, which supports its use in the treatment of abdominal pain caused by cramping.

Ketorolac tromethamine improves the analgesic effect of hyoscine butylbromide in patients with intense cramping pain from gastrointestinal or genitourinary origin.

Data indicate that the oral ketorolac/hyoscinebutylbromide mixture could be a better option than hyoscine butyl bromide alone in the treatment of some acute intense cramping painful conditions.

Comparison of paracetamol and hyoscine-N-butylbromide in the treatment of abdominal pain and cramps due to acute gastroenteritis

HBB and paracetamol were used for symptomatic treatment in AGE patients presenting with abdominal pain and cramps and a significant reduction in pain andCramps was achieved in both patient groups.

Hyoscine butylbromide mode of action on bowel motility: From pharmacology to clinical practice.

This review is the result of the collaboration between a basic scientist and clinicians with the aim of providing an updated overview of the mechanisms of action of HBB and its clinical efficacy to guide not only use in clinical practice, but also future research.

Cardiovascular effects of hyoscine butylbromide in patients under general anaesthesia.

Hyoscine butylbromide generates positive effects on the heart rate and blood pressure of patients under general anaesthesia, representing a possible alternative in the management of intraoperative bradycardia.

The pharmacokinetics of orally administered butylscopolamine in greyhound dogs

Medication control of butylscopolamine's antispasmodic effect on the digestive tract is possible by setting screening limits based on the urinary and faecal drug levels as determined in this study.

Anaphylaxis caused by butylscopolamine bromide: a case report

Butylscopolamine has the potential to cause severe anaphylaxis; hence, identification of the causative agent is important to prevent recurrence of anaphYLaxis.

The effect of hyoscine-N-butylbromide on pain perception during and after hysterosalpingography in infertile women: a systematic review and meta-analysis of randomised controlled trials

Good evidence is provided that prior administration of HBB is effective in reducing induced pain during and after HSG with tolerable side effects.

Canadian Association of Gastroenterology (CAG) Position Statement on the Use of Hyoscine-n-butylbromide (Buscopan) During Gastrointestinal Endoscopy

The Clinical Affairs Committee of the Canadian Association of Gastroenterology conducted systematic reviews and applied the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach to develop recommendations for the use of Buscopan during GI endoscopy.
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