Hyoscine Butylbromide

@article{Tytgat2012HyoscineB,
  title={Hyoscine Butylbromide},
  author={Guido N. J. Tytgat},
  journal={Drugs},
  year={2012},
  volume={67},
  pages={1343-1357}
}
  • G. Tytgat
  • Published 2012
  • Medicine, Biology
  • Drugs
Abdominal cramping and pain is a frequent problem in the adult population of Western countries, with an estimated prevalence of ≤30. [] Key ResultTen placebo-controlled studies have evaluated the efficacy and safety of oral or rectal hyoscine butylbromide. Hyoscine butylbromide was considered beneficial in all of these trials, which supports its use in the treatment of abdominal pain caused by cramping.
Ketorolac tromethamine improves the analgesic effect of hyoscine butylbromide in patients with intense cramping pain from gastrointestinal or genitourinary origin.
TLDR
Data indicate that the oral ketorolac/hyoscinebutylbromide mixture could be a better option than hyoscine butyl bromide alone in the treatment of some acute intense cramping painful conditions.
Cardiovascular effects of hyoscine butylbromide in patients under general anaesthesia.
TLDR
Hyoscine butylbromide generates positive effects on the heart rate and blood pressure of patients under general anaesthesia, representing a possible alternative in the management of intraoperative bradycardia.
The pharmacokinetics of orally administered butylscopolamine in greyhound dogs
TLDR
Medication control of butylscopolamine's antispasmodic effect on the digestive tract is possible by setting screening limits based on the urinary and faecal drug levels as determined in this study.
Anaphylaxis caused by butylscopolamine bromide: a case report
TLDR
Butylscopolamine has the potential to cause severe anaphylaxis; hence, identification of the causative agent is important to prevent recurrence of anaphYLaxis.
Canadian Association of Gastroenterology (CAG) Position Statement on the Use of Hyoscine-n-butylbromide (Buscopan) During Gastrointestinal Endoscopy
TLDR
The Clinical Affairs Committee of the Canadian Association of Gastroenterology conducted systematic reviews and applied the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach to develop recommendations for the use of Buscopan during GI endoscopy.
Comparing hyoscine and drotaverine effects on colon in CT colonography
TLDR
It is concluded that drotaverine can be used as a means to facilitate colonic distension.
Clinical Assessment of the Use of Propinox Hydrochloride and Scopolamine Hydrochloride in the Treatment of Abdominal Colic: A Retrospective, Comparative Study
TLDR
Both treatments demonstrated good efficacy and tolerability in the treatment of abdominal colic pain, in the population evaluated, indicating a therapeutic equivalence between propinox hydrochloride and scopolamine hydrochlorides.
The noradrenergic agent reboxetine plus the antimuscarinic hyoscine butylbromide reduces sleep apnoea severity: a double‐blind, placebo‐controlled, randomised crossover trial
TLDR
It is found that reboxetine plus hyoscine butylbromide reduced OSA severity including overnight hypoxemia via increases in pharyngeal muscle responsiveness, improvements in respiratory control and airway collapsibility without changing the respiratory arousal threshold.
Prophylactic effect of scopolamine butylbromide, a competitive antagonist of muscarinic acetylcholine receptor, on irinotecan-related cholinergic syndrome
TLDR
It is recommended for patients receiving ≥ 150 mg/m2 irinotecan who may develop cholinergic syndrome at high frequency to prophylactically administer scopolamine butylbromide at the next scheduled treatment.
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In conclusion, cyclotropium bromide markedly inhibits gastric emptying and reduces antral contraction amplitude and hyoscine N-butylbromide differed significantly from placebo.
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TLDR
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TLDR
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