Hylan G-F 20 Single-Injection Formulation

@article{Frampton2010HylanG2,
  title={Hylan G-F 20 Single-Injection Formulation},
  author={James E. Frampton},
  journal={Drugs \& Aging},
  year={2010},
  volume={27},
  pages={77-85}
}
Hylan G-F 20, a cross-linked hyaluronic acid derivative, is an elastoviscous, high-molecular-weight (average 6000 kDa) fluid with rheological properties similar to those of knee synovial fluid of healthy young individuals.In a 26-week, randomized, double-blind, multi-centre study in patients with symptomatic primary osteoarthritis of the knee (n = 253), one intraarticular injection of hylan G-F 20 (single-injection formulation) into the target knee significantly relieved pain (as measured by… Expand
Synovial Fluid and Hylan GF 20 Preventing Friction-induced Chondrocyte Apoptosis : Comparison of Human
Objective. Symptomatic osteoarthritis (OA) is a common painful disease with limited treatment options. A rising number of patients with OA have been treated with intraarticular injections ofExpand
Intra-Articular Hyaluronic Acid in the Symptomatic Treatment of Knee Osteoarthritis: A Meta-Analysis of Single-Injection Products
  • Patrice Vincent
  • Medicine
  • Current therapeutic research, clinical and experimental
  • 2019
TLDR
A meta-analysis of published studies relating to IA HA monoinjection trials suggests that monoin injections produce results similar to multi-injections of IA HA in terms of pain relief in the treatment of knee osteoarthritis. Expand
Safety and Tolerability of Intra-Articular Hyaluronic Acid Injection (Sinovial®) in Experimental and Clinical Practice
TLDR
This formulation of Sinovial® has a favorable tolerability profile; no systemic reactions have been reported and most adverse events (AEs) are mild, transient and easily managed local injection site reactions. Expand
Preventing Friction-induced Chondrocyte Apoptosis: Comparison of Human Synovial Fluid and Hylan G-F 20
TLDR
Findings indicate that joint lubrication may prevent chondrocyte apoptosis by lowering the COF and removal of synovial fluid prior to hylan G-F 20 injection may be detrimental to cartilage health. Expand
Efficacy and safety of a single intra-articular injection of 2% hyaluronic acid plus mannitol injection in knee osteoarthritis over a 6-month period ☆
TLDR
It is demonstrated that one single intra-articular injection of non-cross-linked HA reduces joint pain and increases function in patients with KOA over a period of at least 6 months. Expand
SAFETYAND TOLERABILITYOF INTRA-ARTICULARHYALURONICACID INJECTION (SINOVIAL®) IN EXPERIMENTALAND CLINICAL PRACTICE
Osteoarthritis (OA) requires long-term treatment, therefore, tolerability is a key factor in treatment choice. Hyaluronic acid (HA), a glycosaminoglycan with viscoelastic properties, a majorExpand
Clearance kinetics of a hylan-based viscosupplement after intra-articular and intravenous administration in animal models.
TLDR
Results are consistent with the current clinical data that demonstrates safety and effectiveness of an increased volume of hylan G-F 20 injected into the osteoarthritis knee. Expand
[Efficacy and safety of a single intra-articular injection of 2% hyaluronic acid plus mannitol in knee osteoarthritis over a 6-month period].
TLDR
It is demonstrated that one single intra-articular injection of non-cross-linked HA reduces joint pain and increases function in patients with KOA over a period of at least 6 months. Expand
A Search for Factors that Predict the Efficacy of Viscosupplementation in Knee Osteoarthritis
TLDR
Factors that predict clinical response to a single intra-articular injection of Hylan GF-20 did not confirm previous predictors of response to hyaluronate injections, and the need for prospective studies to answer this question was highlighted. Expand
Efficacy and safety of hylan G-F 20 injection in treatment of knee osteoarthritis in Chinese patients: results of a prospective, multicentre, longitudinal study.
TLDR
Hylan G-F 20 is a safe and effective therapy to relieve pain and improve function for up to 1 year in Chinese patients with knee osteoarthritis. Expand
...
1
2
3
...

References

SHOWING 1-10 OF 38 REFERENCES
Viscosupplementation with hylan G-F 20: a 26-week controlled trial of efficacy and safety in the osteoarthritic knee.
TLDR
It is demonstrated that hylan G-F 20 is effective and well tolerated in the management of chronic idiopathic osteoarthritis of the knee and use of rescue therapy was significantly greater in the saline group than in the hylan g-f 20 group. Expand
The role of viscosupplementation with hylan G-F 20 (Synvisc) in the treatment of osteoarthritis of the knee: a Canadian multicenter trial comparing hylan G-F 20 alone, hylan G-F 20 with non-steroidal anti-inflammatory drugs (NSAIDs) and NSAIDs alone.
TLDR
A statistical test for the equivalence, the q-statistic, demonstrated that viscosupplementation with hylan G-F 20 was at least as good or better than continuous NSAID therapy for all outcome measurements except activity restriction. Expand
Efficacy of Hylan G-F 20 and Sodium Hyaluronate in the treatment of osteoarthritis of the knee -- a prospective randomized clinical trial.
TLDR
It appeared that the clinical effectiveness and general patient satisfaction are better amongst patients who received Hylan G-F 20 and Sodium Hyaluronate in patients with osteoarthritis of the knee. Expand
Longterm effects of intraarticular hyaluronan on synovial fluid in osteoarthritis of the knee.
TLDR
Results suggest that one possible mechanism of action of viscosupplementation is to promote endogenous HA production in patients with mild to moderate knee OA following IA Hylan GF-20 injection. Expand
99 CLEARANCE KINETICS OF A SINGLE INJECTION CROSSLINKED HYLAN-BASED VISCOSUPPLEMENT IN A RABBIT MODEL
TLDR
The fluid and gel components from a single injection hyaluronan G-F 20 were cleared from the joint without detectable accumulation in the blood or internal organs, and all of the measurable radioactivity was found within the joint. Expand
Intra-articular distribution and residence time of Hylan A and B: a study in the goat knee.
TLDR
The smaller MW Hylan was removed more rapidly than the higherMW Hylan, and the globules were degraded by a different mechanism involving monocytes/macrophages on the surface of the higher MW globules. Expand
Hylan G-F 20 efficacy on articular cartilage quality in patients with knee osteoarthritis: clinical and MRI assessment
TLDR
In conclusion, intra-articular injections of HA is an effective choice of treatment in patients with knee osteoarthritis. Expand
Single, intra-articular treatment with 6 ml hylan G-F 20 in patients with symptomatic primary osteoarthritis of the knee: a randomised, multicentre, double-blind, placebo controlled trial
TLDR
This placebo-controlled study demonstrated that, in patients with knee osteoarthritis, a single 6 ml intra-articular injection of hylan G-F 20 is safe and effective in providing statistically significant, clinically relevant pain relief over 26 weeks, with a modest difference versus placebo. Expand
A randomized, single-blind comparison of the efficacy and tolerability of hylan G-F 20 and triamcinolone hexacetonide in patients with osteoarthritis of the knee.
TLDR
Viscosupplementation with HG-F 20 resulted in a longer duration of effect than TH with a comparable tolerability profile, and these data support the preferential use of HG-f 20 over TH for treatment of chronic OA knee pain. Expand
Effects of different hyaluronic acid products on synovial fluid NO levels in knee osteoarthritis
TLDR
Intra-articular hyaluronic acid therapy may reduce synovial fluid NO levels and glutathione peroxidase activities in the treatment of patients with knee osteoarthritis, and these effects do not seem to be dependent on the molecular weight and various structural changes of hyaluronan products. Expand
...
1
2
3
4
...