Hygiene Hypothesis and Autoimmune Diseases

@article{Rook2011HygieneHA,
  title={Hygiene Hypothesis and Autoimmune Diseases},
  author={G. Rook},
  journal={Clinical Reviews in Allergy & Immunology},
  year={2011},
  volume={42},
  pages={5-15}
}
  • G. Rook
  • Published 2011
  • Biology, Medicine
  • Clinical Reviews in Allergy & Immunology
  • Throughout the twentieth century, there were striking increases in the incidences of many chronic inflammatory disorders in the rich developed countries. These included autoimmune disorders such as Type 1 diabetes and multiple sclerosis. Although genetics and specific triggering mechanisms such as molecular mimicry and viruses are likely to be involved, the increases have been so rapid that any explanation that omits environmental change is incomplete. This chapter suggests that a series of… CONTINUE READING
    288 Citations

    Figures, Tables, and Topics from this paper.

    Childhood microbial experience, immunoregulation, inflammation and adult susceptibility to psychosocial stressors and depression in rich and poor countries
    • 34
    • Highly Influenced
    • PDF
    The immunology of the allergy epidemic and the hygiene hypothesis
    • 142
    Immunoregulation of multiple sclerosis by gut environmental factors
    • 5
    Clinical Use of Schistosoma mansoni Antigens as Novel Immunotherapies for Autoimmune Disorders

    References

    SHOWING 1-10 OF 110 REFERENCES
    Multiple sclerosis and the hygiene hypothesis
    • 155
    • PDF
    A missing link in the hygiene hypothesis?
    • 261
    • PDF
    Innate immunity and intestinal microbiota in the development of Type 1 diabetes
    • 1,583
    • Highly Influential
    • PDF
    Viral Trigger for Type 1 Diabetes
    • 180
    • PDF
    Helminths and the IBD hygiene hypothesis
    • 206
    Parasites represent a major selective force for interleukin genes and shape the genetic predisposition to autoimmune conditions
    • 235
    • PDF
    Type 1 diabetes: lessons for other autoimmune diseases?
    • 61
    TIM-1, hepatitis A virus and the hygiene theory of atopy: association of TIM-1 with atopy.
    • 21