Hydroxyurea is a carbonic anhydrase inhibitor.

  title={Hydroxyurea is a carbonic anhydrase inhibitor.},
  author={Andrea Scozzafava and Claudiu T. Supuran},
  journal={Bioorganic & medicinal chemistry},
  volume={11 10},
The interaction of hydroxyurea with the cytosolic isozymes of carbonic anhydrase (CA), hCA I and hCA II has been investigated by means of kinetic and spectroscopic techniques. Hydroxyurea acts as a weak, non-competitive inhibitor of both isozymes, for the 4-nitrophenyl acetate esterase activity, with inhibition constants around 0.1 mM for both isozymes. The… CONTINUE READING