Hydroxyurea downregulates endothelin-1 gene expression and upregulates ICAM-1 gene expression in cultured human endothelial cells

@article{Brun2003HydroxyureaDE,
  title={Hydroxyurea downregulates endothelin-1 gene expression and upregulates ICAM-1 gene expression in cultured human endothelial cells},
  author={Manuel Brun and Sandrine Bourdoulous and Pierre Olivier Couraud and Jacques E Elion and Rajagopal Krishnamoorthy and Claudine L Lapoum{\'e}roulie},
  journal={The Pharmacogenomics Journal},
  year={2003},
  volume={3},
  pages={215-226}
}
ABSTRACTThe clinical efficacy of oral hydroxyurea (HU) in adults and children with sickle cell anemia (SCA) cannot solely be explained by its ability to enhance fetal hemoglobin (HbF) expression. Since increased adherence of sickle red blood cells to vascular endothelium is a possible contributing factor to vaso-occlusive crisis (VOC), we explored the effect of HU on human endothelial cell (EC) lines (TrHBMEC and EA-hy 926). We demonstrated that HU, in a dose-dependent and reversible manner… CONTINUE READING
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