Hydroxyurea as an inhibitor of human immunodeficiency virus-type 1 replication.

  title={Hydroxyurea as an inhibitor of human immunodeficiency virus-type 1 replication.},
  author={Franco Lori and Andrei G. Malykh and Andrea Cara and Deming Sun and John N. Weinstein and Julianna Lisziewicz and Robert C. Gallo},
  volume={266 5186},
Hydroxyurea, a drug widely used in therapy of several human diseases, inhibits deoxynucleotide synthesis--and, consequently, DNA synthesis--by blocking the cellular enzyme ribonucleotide reductase. Hydroxyurea inhibits human immunodeficiency virus-type 1 (HIV-1) DNA synthesis in activated peripheral blood lymphocytes by decreasing the amount of intracellular deoxynucleotides, thus suggesting that this drug has an antiviral effect. Hydroxyurea has now been shown to block HIV-1 replication in… CONTINUE READING
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