Hydroxyurea as an inhibitor of hepatitis C virus RNA replication


Hepatitis C virus (HCV) is the main causative agent of chronic liver disease, which may develop into liver cirrhosis and hepatocellular carcinoma. By using a recently developed reporter assay system in which genome-length HCV RNA replicates efficiently, we found that hydroxyurea (HU), a DNA synthesis inhibitor, inhibited HCV RNA replication. Moreover, we demonstrated that the anti-HCV activity of the combination of IFN-alpha and HU was higher than that of IFN-alpha alone. These results suggest that HU may be an effective anti-HCV reagent that can be used not only singly but also in combination with IFN-alpha to treat chronic hepatitis C.

DOI: 10.1007/s00705-010-0624-1

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@article{Nozaki2010HydroxyureaAA, title={Hydroxyurea as an inhibitor of hepatitis C virus RNA replication}, author={Akito Nozaki and Manabu Morimoto and Masaaki Kondo and Takashi Oshima and Kazushi Numata and Shin Fujisawa and Takeshi Kaneko and Eiji Miyajima and Satoshi Morita and Kyoko Mori and Masanori Ikeda and Nobuyuki Kato and Katsuaki Tanaka}, journal={Archives of Virology}, year={2010}, volume={155}, pages={601-605} }