Hydroxyurea: effect on growth, structure, and [3H]thymidine uptake of Trypanosoma brucei procyclic culture forms.


Hydroxyurea (HU) in concentrations above 50 micrograms/ml reversibly inhibited cell division of Trypanosoma brucei brucei stock STIB 336 procyclic culture forms, but not growth of individual cells. The volume of the nucleus and of the cytoplasm increased in the presence of the drug as did the percentage of cells with 2 kinetoplasts. Electron microscopy… (More)


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