Hydroxytyrosol prevents reduction in liver activity of Δ-5 and Δ-6 desaturases, oxidative stress, and depletion in long chain polyunsaturated fatty acid content in different tissues of high-fat diet fed mice

@inproceedings{Valenzuela2017HydroxytyrosolPR,
  title={Hydroxytyrosol prevents reduction in liver activity of Δ-5 and Δ-6 desaturases, oxidative stress, and depletion in long chain polyunsaturated fatty acid content in different tissues of high-fat diet fed mice},
  author={Rodrigo Valenzuela and Francisca Echeverr{\'i}a and Macarena Ortiz and Miguel {\'A}ngel Rinc{\'o}n-Cervera and Alejandra Espinosa and Mar{\'i}a Catalina Hern{\'a}ndez-Rodas and Paola Guadalupe Illesca and Alfonso Valenzuela and Luis A Videla},
  booktitle={Lipids in Health and Disease},
  year={2017}
}
BackgroundEicosapentaenoic acid (EPA, C20:5n-3), docosahexaenoic acid (DHA, C22:6n-3) and arachidonic acid (AA, C20:4n-6) are long-chain polyunsaturated fatty acids (LCPUFAs) with relevant roles in the organism. EPA and DHA are synthesized from the precursor alpha-linolenic acid (ALA, C18:3n-3), whereas AA is produced from linoleic acid (LA, C18:2n-6) through the action of Δ5 and Δ6-desaturases. High-fat diet (HFD) decreases the activity of both desaturases and LCPUFA accretion in liver and… CONTINUE READING

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