Hydroxytyrosol inhibits growth and cell proliferation and promotes high expression of sfrp4 in rat mammary tumours.

@article{GranadosPrincipal2011HydroxytyrosolIG,
  title={Hydroxytyrosol inhibits growth and cell proliferation and promotes high expression of sfrp4 in rat mammary tumours.},
  author={Sergio M Granados-Principal and Jos{\'e} Luis Quiles and C{\'e}sar Ram{\'i}rez-Tortosa and Pedro Camacho-Corencia and Pedro S{\'a}nchez-Rovira and Laura Vera-Ramirez and MCarmen Ramirez-Tortosa},
  journal={Molecular nutrition & food research},
  year={2011},
  volume={55 Suppl 1},
  pages={
          S117-26
        }
}
SCOPE Hydroxytyrosol (a phenolic compound derived from virgin olive oil) has demonstrated an anti-tumour effect in several tumour cell lines in addition to other health-related properties. The aim of this study was to investigate, for the first time in an animal model of experimental mammary carcinoma, the anti-cancer ability of hydroxytyrosol and to discover which pathways are modified by hydroxytyrosol. METHODS AND RESULTS Dimethylbenz[α]anthracene-induced mammary tumours were induced in 28… CONTINUE READING
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