Hydroxytyrosol, a product from olive oil, reduces colon cancer growth by enhancing epidermal growth factor receptor degradation.

@article{Terzuoli2016HydroxytyrosolAP,
  title={Hydroxytyrosol, a product from olive oil, reduces colon cancer growth by enhancing epidermal growth factor receptor degradation.},
  author={Erika Terzuoli and Antonio Giachetti and Marina Ziche and Sandra Donnini},
  journal={Molecular nutrition & food research},
  year={2016},
  volume={60 3},
  pages={519-29}
}
SCOPE We studied the effects and mechanism of 2-(3,4-dihydroxyphenil)ethanol (or hydroxytyrosol, HT), a polyphenol from extra virgin olive oil, investigating the regulation of epidermal growth factor receptor (EGFR) expression in colon tumour cells. METHODS AND RESULTS We demonstrate that HT significantly downregulates EGFR expression in human colorectal adenocarcinoma cells HT-29, CaCo2, and WiDr, and in HT-29 xenografts. HT accelerates EGFR degradation by reducing its half-life… CONTINUE READING
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