Hydroxytyrosol, a natural molecule occurring in olive oil, induces cytochrome c-dependent apoptosis.

@article{Ragione2000HydroxytyrosolAN,
  title={Hydroxytyrosol, a natural molecule occurring in olive oil, induces cytochrome c-dependent apoptosis.},
  author={Fulvio Della Ragione and Valeria Cucciolla and Adriana Borriello and Valentina Della Pietra and Gabriele Pontoni and Luigi Racioppi and Caterina Manna and Patrizia Galletti and Vincenzo Zappia},
  journal={Biochemical and biophysical research communications},
  year={2000},
  volume={278 3},
  pages={733-9}
}
2-(3,4-Dihydroxyphenyl)ethanol (DPE), a naturally occurring phenolic antioxidant molecule found in olive oil, has been reported to exert several biological and pharmacological activities. We studied the effect of this compound on the proliferation and survival of HL60 cell line. Concentrations from 50 to 100 microM DPE, comparable to its olive oil content, caused a complete arrest of HL60 cell proliferation and the induction of apoptosis. This was demonstrated by flow cytometric analyses, poly… CONTINUE READING

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