Hydroxytyrosol, a natural antioxidant from olive oil, prevents protein damage induced by long-wave ultraviolet radiation in melanoma cells.
@article{DAngelo2005HydroxytyrosolAN, title={Hydroxytyrosol, a natural antioxidant from olive oil, prevents protein damage induced by long-wave ultraviolet radiation in melanoma cells.}, author={Stefania D’Angelo and Diego Ingrosso and Valentina Migliardi and Alvara Sorrentino and Giovanna Donnarumma and Adone Baroni and Lucia Masella and Maria Antonietta Tufano and Marcello Zappia and Patrizia Galletti}, journal={Free radical biology \& medicine}, year={2005}, volume={38 7}, pages={ 908-19 } }
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References
SHOWING 1-10 OF 89 REFERENCES
Beneficial effects of quercetin on oxidative stress induced by ultraviolet A
- BiologyClinical and experimental dermatology
- 2001
This study demonstrates that exposure of rats to UVA leads to oxidative stress as reflected by increased MDA levels and reduced enzymatic antioxidant levels, and shows that quercetin may be useful in reducing or preventing photobiologic damage.
Olive oil hydroxytyrosol protects human erythrocytes against oxidative damages.
- BiologyThe Journal of nutritional biochemistry
- 1999
Hydroxytyrosol, a natural molecule occurring in olive oil, induces cytochrome c-dependent apoptosis.
- BiologyBiochemical and biophysical research communications
- 2000
It is suggested that DPE down-regulates the immunological response, thus explaining the well-known antinflammatory and chemopreventive effects of olive oil at the intestinal level.
Dietary tomato paste protects against ultraviolet light-induced erythema in humans.
- MedicineThe Journal of nutrition
- 2001
It is feasible to achieve protection against UV light-induced erythema by ingestion of a commonly consumed dietary source of lycopene, and no significant difference between groups was found at wk 4 of treatment.
The Role of H2O2 as a Mediator of UVB-induced Apoptosis in Keratinocytes
- Biology, ChemistryFree radical research
- 2003
A ROS-independent pathway of UVB-induced apoptosis is suggested, as the generation of H2O2 does not contribute to the induction of apoptosis, and activation of ERK only blocks H 2O2-dependent apoptosis but has no impact onUVB- induced apoptosis.
Botanical antioxidants for chemoprevention of photocarcinogenesis.
- MedicineFrontiers in bioscience : a journal and virtual library
- 2002
The use of botanical antioxidants, in combination with the use of sunscreens and educational efforts to avoid excessive sun exposure, may be an effective strategy for reduction of incidence of skin cancer and other UV-mediated damage in humans.
The protective effect of the olive oil polyphenol (3,4-dihydroxyphenyl)-ethanol counteracts reactive oxygen metabolite-induced cytotoxicity in Caco-2 cells.
- Biology, ChemistryThe Journal of nutrition
- 1997
Dietary intake of olive oil polyphenols may lower the risk of reactive oxygen metabolite-mediated diseases such as some gastrointestinal diseases and atherosclerosis, and the data demonstrate that (3,4-dihydroxyphenyl)ethanol can act as a biological antioxidant in a cell culture experimental model.
Diverse effects of natural antioxidants on cyclosporin cytotoxicity in rat renal tubular cells.
- BiologyNephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
- 2005
A key role for glutathione is confirmed in protecting cells from CsA-induced adverse effects and the results indicate that the diverse cytoprotective effects of the antioxidants tested in these studies were not directly related to their scavenging capabilities.
Effects of UV light and tumor promoters on endogenous vitamin E status in mouse skin.
- Chemistry, MedicineCarcinogenesis
- 2000
The results indicate that UVB and tumor promoting chemicals all exert qualitatively different effects on epidermal TH status and thatUVB and TPA trigger an adaptive response involving epider mal TH accumulation.
Protection against ultraviolet B radiation-induced photocarcinogenesis in hairless mice by green tea polyphenols.
- Biology, MedicineCarcinogenesis
- 1991
It is suggested that consumption of green tea may reduce the risk of some forms of human cancer induced by both physical and chemical environmental carcinogens.