Hydroxysteroid dehydrogenases (HSDs) in bacteria: a bioinformatic perspective.

  title={Hydroxysteroid dehydrogenases (HSDs) in bacteria: a bioinformatic perspective.},
  author={Michael Kisiela and Adam Skarka and Bettina Ebert and Edmund Maser},
  journal={The Journal of steroid biochemistry and molecular biology},
  volume={129 1-2},
Steroidal compounds including cholesterol, bile acids and steroid hormones play a central role in various physiological processes such as cell signaling, growth, reproduction, and energy homeostasis. Hydroxysteroid dehydrogenases (HSDs), which belong to the superfamily of short-chain dehydrogenases/reductases (SDR) or aldo-keto reductases (AKR), are important enzymes involved in the steroid hormone metabolism. HSDs function as an enzymatic switch that controls the access of receptor-active… CONTINUE READING


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