Hydroxysafflor yellow A improves learning and memory in a rat model of vascular dementia by increasing VEGF and NR1 in the hippocampus

@article{Zhang2013HydroxysafflorYA,
  title={Hydroxysafflor yellow A improves learning and memory in a rat model of vascular dementia by increasing VEGF and NR1 in the hippocampus},
  author={Nan Zhang and Mengya Xing and Yiyi Wang and Hao Liang and Zhuo Yang and Fudong Shi and Yan Cheng},
  journal={Neuroscience Bulletin},
  year={2013},
  volume={30},
  pages={417-424}
}
Hydroxysafflor yellow A (HSYA) has angiogenesisregulating and neuro-protective effects, but its effects on vascular dementia (VaD) are unknown. In this study, 30 adult Sprague-Dawley rats were randomly allocated to five groups: normal, sham-operation, VaD alone (bilateral carotid artery occlusion), VaD plus saline (control), and VaD plus HSYA. One week after operation, the HSYA group received one daily tail-vein injection of 0.6 mg/100 g HSYA for two weeks. Five weeks after operation, the… CONTINUE READING

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Hydroxysafflor Yellow A: A Promising Therapeutic Agent for a Broad Spectrum of Diseases

Evidence-based complementary and alternative medicine : eCAM • 2018
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