Hydroxysafflor yellow A enhances survival of vascular endothelial cells under hypoxia via upregulation of the HIF-1 alpha-VEGF pathway and regulation of Bcl-2/Bax.

@article{Ji2008HydroxysafflorYA,
  title={Hydroxysafflor yellow A enhances survival of vascular endothelial cells under hypoxia via upregulation of the HIF-1 alpha-VEGF pathway and regulation of Bcl-2/Bax.},
  author={Deng Bo Ji and Mei Cai Zhu and Bing Zhu and Yi Zhun Zhu and Chang Ling Li and Jia Jia Ye and Hai Bo Zhu},
  journal={Journal of cardiovascular pharmacology},
  year={2008},
  volume={52 2},
  pages={191-202}
}
Hydroxysafflor yellow A (HSYA) is a component of the flower Carthamus tinctorius L. The present investigation determines whether HSYA can modify the effects of hypoxia on vascular endothelial cells (EC) and its mechanisms. Human EC line (EAhy926) viability was determined using the MTT assay. EC cycle phase distribution was done with PI staining and flow… CONTINUE READING